18962-07-7Relevant articles and documents
An improved process for the preparation of pimavanserin tartrate
Wu, Caijiao,Zhou, Qifan,Song, Dake,Li, Hui,Bao, Changshun,Liu, Xuelong,Bao, Xuefei,Chen, Guoliang
, p. 480 - 485 (2019)
A practical synthetic route to pimavanserin tartrate, in which the target compound was obtained with 99.84% purity and in 46% total yield via a 5-step synthesis starting from 4-hydroxybenzaldehyde and (4-fluorophenyl)methanamine, is reported. The main advantages of the route include inexpensive starting materials, mild reaction conditions and an acceptable overall yield.
Application of pimavanserin in preparation of antitumor drugs
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Paragraph 0021; 0022, (2021/08/21)
The invention relates to application of pimavanserin in preparation of antitumor drugs, belongs to the technical field of medicines, and particularly relates to novel application of pimavanserin in preparation of antitumor drugs. The structural formula of the pimavanserin is shown in the formula I. The biological activity test of the compound shows that the compound has antitumor activity and is a novel antitumor drug.
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN
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Paragraph 0151, (2018/04/17)
The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.