189747-29-3 Usage
Description
5-Amino-2-chloropyrimidine-4-carboxamide is an organic compound that serves as a key building block in the synthesis of Favipiravir (F103350), an antiviral medication.
Used in Pharmaceutical Industry:
5-Amino-2-chloropyrimidine-4-carboxamide is used as an intermediate in the production of Favipiravir for its antiviral properties.
Used in Antiviral Applications:
5-Amino-2-chloropyrimidine-4-carboxamide contributes to the development of Favipiravir, which is employed as an antiviral agent, specifically for the treatment of advanced Ebola virus infection. In a small animal model, Favipiravir has been shown to suppress the replication of Zaire Ebola virus and prevent a lethal outcome in 100% of the animals, making it a potential candidate for the treatment of Ebola hemorrhagic fever.
Check Digit Verification of cas no
The CAS Registry Mumber 189747-29-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,7,4 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 189747-29:
(8*1)+(7*8)+(6*9)+(5*7)+(4*4)+(3*7)+(2*2)+(1*9)=203
203 % 10 = 3
So 189747-29-3 is a valid CAS Registry Number.
189747-29-3Relevant articles and documents
NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE
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, (2021/06/26)
The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.
Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor
Rewcastle, Gordon W.,Bridges, Alexander J.,Fry, David W.,Rubin, J. Ronald,Denny, William A.
, p. 1820 - 1826 (2007/10/03)
A series of 6-substituted 4-anilinopyrimido[5,4-d]pyrimidines has been prepared and shown to be potent inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). These compounds are structurally related to the pyrido[3,2-d]