1898-85-7

Basic information

• Product Name: DIBENZO[B,F]THIEPIN-10(11H)-ONE
• Synonyms: DIBENZO[B,F]THIEPIN-10(11H)-ONE;10,11-Dihydrodibenzo[b,f]thiepin-10-one
• CAS NO: 1898-85-7
• Molecular Formula: C₁₄H₁₀OS
• Molecular Weight: 226.29
• Mol File: 1898-85-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.258
• CAS DataBase Reference: DIBENZO[B,F]THIEPIN-10(11H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: DIBENZO[B,F]THIEPIN-10(11H)-ONE(1898-85-7)
• EPA Substance Registry System: DIBENZO[B,F]THIEPIN-10(11H)-ONE(1898-85-7)

Safety Data

• Hazardous Substances Data: 1898-85-7(Hazardous Substances Data)

Usage

General Description

Dibenzo[b,f]thiepin-10(11H)-one, also known as loxapine, is a tricyclic dibenzothiepin derivative with antipsychotic and sedative properties. It is used in the treatment of schizophrenia and other psychoses, and works by blocking dopamine receptors in the brain, as well as serotonin and histamine receptors. Loxapine has been shown to be effective in reducing symptoms such as hallucinations, delusions, and disorganized thinking in patients with schizophrenia, and is available in both oral and injectable forms for acute and maintenance treatment. Common side effects of loxapine include drowsiness, dizziness, dry mouth, and constipation, and it should be used with caution in patients with cardiovascular disease or epilepsy.

Upstream product

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Downstream Products

• 1725-32-2 10-chloro-10,11-dihydro-dibenzo[b,f]thiepine 
• 139305-20-7 1-(10,11-Dihydro-dibenzo[b,f]thiepin-10-yl)-4-((E)-3-phenyl-allyl)-piperazine; compound with oxalic acid 
• 87033-44-1 10,11-dihydrodibenzothiepin-10-carboxylic acid 
• 87033-42-9 10,11-dihydrodibenzothiepin-10-carboxamide 
• 87033-79-2 10-(3-dimethylaminopropyl)-10,11-dihydrodibenzothiepin-10-carbonitrile hydrogen oxalate 
• 22012-13-1 1-dibenzo[b,f]thiepin-10-yl-4-methyl-piperazine 
• 1526-83-6 10-(4-Methyl-piperazino)-10,11-dihydro-dibenzothiepin 

Relevant articles and documents

The rearrangement of 10 bromo 10,11 dihydrodibenzo[b,f]thiepin 11 one and related compounds in an alkaline solution

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Redox-Neutral α-Arylation of Alkyl Nitriles with Aryl Sulfoxides: A Rapid Electrophilic Rearrangement

A facile α-arylation of nitriles has been developed by simply introducing Tf2O and DABCO to the mixture of nitriles and aryl sulfoxides. The transformation consists of two sequential steps: (i) Tf2O-initiated electrophilic assembly a

ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

The present invention relates to a novel compound represented by chemical formula 1, and an organic electroluminescent device comprising the same. The compound according to the present invention can improve light-emitting efficiency, driving voltage, and lifespan of the organic electroluminescent device by being used in an organic layer of the organic electroluminescent device.COPYRIGHT KIPO 2016