18994-78-0 Usage
Description
N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE, also known as 1-(2-Chloroethyl)imidazole Hydrochloride, is an organic compound with the chemical formula C7H8ClN2. It is a derivative of imidazole and is characterized by the presence of a chloroethyl group attached to the imidazole ring. N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE is known for its potential applications in the pharmaceutical industry, particularly in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE is used as a chemical intermediate for the synthesis of various biologically active compounds. Its unique structure allows it to be a valuable building block in the development of new drugs with specific therapeutic properties.
Used in the Preparation of Substituted Pyrazolo[1,5-a]pyridine Compounds:
N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE is used as a key intermediate in the preparation of substituted pyrazolo[1,5-a]pyridine compounds. These compounds have been identified as potential RET kinase inhibitors, which are important targets for the treatment of various cancers, including non-small cell lung cancer, medullary thyroid cancer, and other RET-driven malignancies. The inhibition of RET kinase activity by these compounds can help in the regulation of cell growth and differentiation, thereby exhibiting anti-cancer properties.
Check Digit Verification of cas no
The CAS Registry Mumber 18994-78-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,9 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18994-78:
(7*1)+(6*8)+(5*9)+(4*9)+(3*4)+(2*7)+(1*8)=170
170 % 10 = 0
So 18994-78-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H7ClN2.ClH/c6-1-3-8-4-2-7-5-8;/h2,4-5H,1,3H2;1H
18994-78-0Relevant articles and documents
Synthesis of azolylethyl benzhydryl ethers, analogs of diphenhydramine
Burdeinyi,Popkov,Kharchevnikova
body text, p. 936 - 939 (2010/10/03)
Alternative approaches to the preparation of azolylethyl benzhydryl ethers have been studied. It was shown that the reaction of diphenylmethyl halide with 2-(azol-1-yl)ethanol in the presence of triethylamine is the optimum way. An efficient method for the synthesis of 2-(imidazol-1-yl)ethanol using phase-transfer catalysis has been developed.
