189954-96-9

Basic information

• Product Name: Firocoxib
• Synonyms: FIROCOXIB;2(5H)-Furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl-;3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2- one;3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;Equioxx;Equixx;Librens;ML 1785713
• CAS NO: 189954-96-9
• Molecular Formula: C17H20O5S
• Molecular Weight: 336.4
• EINECS: 200-001-2
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;THIOCYMETIN
• Mol File: 189954-96-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 78-80°C
• Boiling Point: 563.9°Cat760mmHg
• Flash Point: 294.8°C
• Appearance: /
• Density: 1.31
• Vapor Pressure: 9.72E-13mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Firocoxib(CAS DataBase Reference)
• NIST Chemistry Reference: Firocoxib(189954-96-9)
• EPA Substance Registry System: Firocoxib(189954-96-9)

Safety Data

• Hazardous Substances Data: 189954-96-9(Hazardous Substances Data)

Usage

Description

Firocoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, which is an enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. It is a white solid and is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs. The brand name for Firocoxib is Equioxx (Merial).

Uses

Used in Veterinary Medicine:
Firocoxib is used as an anti-inflammatory and analgesic agent for the control of pain and inflammation associated with osteoarthritis in horses and dogs. It is a selective COX-2 inhibitor, which means it specifically targets the COX-2 enzyme responsible for inflammation and pain without affecting the COX-1 enzyme, which is involved in normal physiological processes.
Used in Antimicrobial Applications:
Firocoxib is also used as an antibacterial agent in veterinary medicine. Its exact mechanism of action in this context is not provided in the materials, but it is likely that it contributes to the overall treatment and management of infections in animals.
Used in Osteoarthritis Treatment:
Firocoxib is used as a treatment for osteoarthritis in dogs and horses, helping to decrease lameness, induce analgesia, and improve the range of motion. It is administered at doses of 5 mg/kg per day for dogs and 0.1 mg/kg per day for horses.

Veterinary Drugs and Treatments

Firocoxib is indicated in dogs and horses for the control of pain and inflammation associated with osteoarthritis. A chewable tablet form for dogs and an oral paste for horses are available. Like other NSAIDs, firocoxib can be useful for treating fever, pain, and/or inflammation associated with other conditions, postsurgery, trauma, etc. Firocoxib may also be useful in other species, but information is scant regarding its safety and efficacy. One study in cats (McCann, Rickes et al. 2005) evaluating firocoxib in experimentally induced pyrexia, demonstrated that the drug was effective after a single oral dose in preventing or attenuating pyrexia at all doses studied (0.75 – 3 mg/kg).

InChI:InChI=1/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3

Upstream product

• 246869-15-8 2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester 
• 100-68-5 methyl-phenyl-thioether 
• 53207-58-2 2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 71867-98-6 2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 246869-08-9 2-(cyclopropylmethoxy)acetic acid 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 400-38-4 isopropyl Trifluoroacetate 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 88324-55-4 2-bromo-2-methyl-1-[4-(methylsulfanyl)phenyl]propan-1-one 
• 102697-45-0 (4-methylsulfonylphenyl)-2-oxo-acetic acid ethyl ester 
• 62936-31-6 (4-methylsulfanylphenyl)oxoacetic acid ethyl ester 
• 300355-18-4 (4-methanesulfonyl-phenyl)-acetic acid methyl ester 
• 2386-57-4 methanesulfonic acid sodium salt 
• 616-38-6 carbonic acid dimethyl ester 

Relevant articles and documents

Non-luo kaoxi intermediate preparation method (by machine translation)

The invention relates to a preparation method of the midbody non-luo kaoxi, belongs to the technical field of pharmacy. The invention provides a preparation method includes: a raw material first after the reaction with the acyl chloride reagent, with in addition a raw material in the presence of a reaction, after treatment, to obtain the target product. The method of the invention can be the operability is strong, is beneficial to the industrial production of operation and cost control. (by machine translation)

Method for preparing firocoxib

The invention relates to the technical field of medicines and particularly relates to a method for preparing firocoxib. Raw materials used in the preparation method are conventional reagents in the market, thioanisole which is easily volatized and has str

Aryl Methyl Sulfone Construction from Eco-Friendly Inorganic Sulfur Dioxide and Methyl Reagents

A three-component cross-coupling protocol of boronic acid, sodium metabisulfite, and dimethyl carbonate was developed for the construction of significant functional methyl sulfones, in which introduction of sulfur dioxide at the last stage was successfully achieved in one step. Inorganic sodium metabisulfite was used as an eco-friendly sulfur dioxide source. Green dimethyl carbonate was employed as methyl reagent in this transformation. Diverse functional methyl sulfones were obtained from various readily available boronic acids. Notably, the last-stage modification of pharmaceuticals and the synthesis of Firocoxib were efficiently established through this strategy.