190276-75-6

Basic information

• Product Name: (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone
• Synonyms: (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone
• CAS NO: 190276-75-6
• Molecular Weight: 332.38
• Mol File: 190276-75-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone(190276-75-6)
• EPA Substance Registry System: (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone(190276-75-6)

Safety Data

• Hazardous Substances Data: 190276-75-6(Hazardous Substances Data)

Upstream product

• 67579-92-4 3-methoxy-4-nitrobenzoic acid chloride 
• 180340-57-2 5,6,7,8-tetra-hydro-4H-thieno[3,2-b]azepine 
• 94252-22-9 6,7-dihydro-5H-benzo[b]thiophene-4-one O-tosyloxime 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 4751-61-5 4,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-5-one 
• 19995-19-8 4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime 
• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 137046-59-4 3-(3-Methoxycarbonyl-propionylamino)-thiophene-2-carboxylic acid methyl ester 
• 137046-61-8 4H-thieno<3,2-b>azepine-5,8(6H,7H)-dione 

Downstream Products

• 190276-13-2 biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide 
• 190276-12-1 biphenyl-2-carboxylic acid [2-methoxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide 
• 190276-23-4 N-[2-(3-chloropropoxy)-4-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-(1,1'-biphenyl)-2-carboxamide 
• 190276-17-6 [2-[(biphenyl-2-carbonyl)-amino]-5-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenoxy]-acetic acid 
• 190276-16-5 [2-[(biphenyl-2-carbonyl)-amino]-5-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenoxy]-acetic acid ethyl ester 
• 190276-25-6 N-[2-(4-chlorobutoxy)-4-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-(1,1'-biphenyl)-2-carboxamide 
• 190276-53-0 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid 
• 190276-52-9 ethyl 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyrate 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine Derivatives: Novel Arginine Vasopressin Antagonists

A variety of novel heterocyclic compounds having thienoazepine, pyrroloazepine, furoazepine, and thienodiazepine skeletons were synthesized, most of which exhibited potent antagonism of [3H]-AVP specific binding in assays using rat liver (V1), rat kidney (V2), human platelet plasma membranes, and recombinant human CHO cells (V2), as well as antagonizing AVP-induced hypertension in rats (V1, intravenous) and showing a diuretic effect in rats (V2, oral). By detailed studies of the structure-activity relationships of these compounds, the thienoazepine derivative 1 was found to be a very potent combined V1 and V2 antagonist. After further pharmacological and toxicological evaluation as well as physical properties, the hydrochloride 2 (JTV-605) of compound 1 was selected for clinical studies as a potent AVP antagonist with a long duration of action.