19029-70-0

Basic information

• Product Name: 1,2-diamino-9-pentofuranosyl-7,9-dihydro-1H-purine-6,8-dione
• CAS NO: 19029-70-0
• Molecular Formula: C₁₀H₁₄N₆O₆
• Molecular Weight: 314.2548
• Mol File: 19029-70-0.mol
• Article Data: 1

Chemical Properties

• Density: 2.5g/cm³
• Refractive Index: 2.04
• CAS DataBase Reference: 1,2-diamino-9-pentofuranosyl-7,9-dihydro-1H-purine-6,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-diamino-9-pentofuranosyl-7,9-dihydro-1H-purine-6,8-dione(19029-70-0)
• EPA Substance Registry System: 1,2-diamino-9-pentofuranosyl-7,9-dihydro-1H-purine-6,8-dione(19029-70-0)

Safety Data

• Hazardous Substances Data: 19029-70-0(Hazardous Substances Data)

Usage

Type of compound

Derivative of adenine

Analog

Adenosine

Structure similarity

Nucleic acid adenine

Biological importance

Precursor for adenosine triphosphate (ATP) production

ATP role

Provides energy for cellular processes

Potential use

Pharmaceuticals and drug development

Similarity to adenosine

Potential effects on cell metabolism and function

Upstream product

• 19039-33-9 1-amino-guanosine 
• 129662-49-3 1,7-diamioguaosine 

Downstream Products

• 121288-39-9 loxoribine 
• 1053631-47-2 1,2-Diamino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7-((E)-3-phenyl-allyl)-7,9-dihydro-1H-purine-6,8-dione 
• 1053627-83-0 1-Amino-7-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropyl]-8-oxoguanosine 
• 1053271-16-1 1,2-Diamino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-hydroxy-propyl}-7,9-dihydro-1H-purine-6,8-dione 

Relevant articles and documents

ELECTROPHILIC AMINATION OF GUANINE DERIVATIVES. MECHANISM FOR FORMATION OF 8-AMINOGUANINE DERIVATIVES

A study of the mechanism of 8-aminoguanosine formation in the reaction of guanosine with hydroxylamine-O-sulfonic acid (HAOS) revealed that the reaction proceeds in three steps; 1) electrophilic N-7 amination by HAOS, 2) nucleophilic C-8 hydroxyamination by NH2OH accompanied by elimination of the N-7 amino group and by aromatization, and finally 3) the reduction of the C-8 hydroxyamino group by NH2OH to give 8-aminoguanosine.The significance of formation of the 7-aminoguanosine intermediate is discussed briefly in relation to thr reaction of carcinogenic arylamines and arylhydroxylamines with cellular DNA.