19031-66-4

Basic information

• Product Name: Benzene, (3-fluoro-3-methylbutyl)-
• CAS NO: 19031-66-4
• Molecular Formula: C11H15F
• Molecular Weight: 166.239
• Mol File: 19031-66-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzene, (3-fluoro-3-methylbutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (3-fluoro-3-methylbutyl)-(19031-66-4)
• EPA Substance Registry System: Benzene, (3-fluoro-3-methylbutyl)-(19031-66-4)

Safety Data

• Hazardous Substances Data: 19031-66-4(Hazardous Substances Data)

Upstream product

• 1361152-14-8 tert-butyl 2,2-dimethyl-4-phenylbutaneperoxoate 
• 2550-26-7 4-Phenyl-2-butanone 
• 6683-51-8 2-methyl-4-phenyl-1-butene 
• 52017-21-7 (3-bromo-3-methyl-n-butyl)benzene 
• 103-05-9 4-phenyl-2-methyl-2-butanol 
• 917-54-4 methyllithium 

Downstream Products

• 828282-52-6 (1,1-dimethyl-3-phenylpropyl)diphenylphosphine 
• 79399-21-6 (2-methyl-4-phenylbutan-2-yl)(phenyl)sulfane 
• 1032065-15-8 (3-cyclopentyl-3-methylbutyl)benzene 
• 1032065-06-7 2-(1,3-cyclopentadienyl)-2-methyl-4-phenylbutane 
• 1032065-04-5 2-(1,4-cyclopentadienyl)-2-methyl-4-phenylbutane 

Relevant articles and documents

Dehydroxylative Fluorination of Tertiary Alcohols

A large number of fluorination methods have been developed, but the construction of a tertiary C-F bond remains challenging. Herein, we describe an efficient dehydroxylative fluorination of tertiary alcohols with Selectfluor via the activation of a hydroxyl group by a Ph2PCH2CH2PPh2/ICH2CH2I system. Although the reagents appear to be not compatible (Selectfluor with the phosphine and I- generated in situ), the reactions occur rapidly to give the desired products in moderate to high yields. This work may present a new discovery in fluorination of alcohols since the reported methods are mainly limited to primary and secondary alcohols.

Predictable site-selective radical fluorination of tertiary ethers

In this communication, we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers, enabled by synergistic photocatalysis and organocatalysis. This catalytic combination allows for exclusi

Nucleophilic Substitution of Aliphatic Fluorides via Pseudohalide Intermediates

A method for aliphatic fluoride functionalization with a variety of nucleophiles has been reported. Carbon–fluoride bond cleavage is thermodynamically driven by the use of silylated pseudohalides TMS-OMs or TMS-NTf2, resulting in the formation of TMS-F and a trapped aliphatic pseudohalide intermediate. The rate of fluoride/pseudohalide exchange and the stability of this intermediate are such that little rearrangement is observed for terminal fluoride positions in linear aliphatic fluorides. The ability to convert organofluoride positions into pseudohalide groups allows facile nucleophilic attack by a wide range of nucleophiles. The late introduction of the nucleophiles also allows for a wide range of functional-group tolerance in the coupling partners. Selective alkyl fluoride mesylation is observed in the presence of other alkyl halides, allowing for orthogonal synthetic strategies.