19031-70-0

Basic information

• Product Name: Benzene, (1-fluoropropyl)-
• CAS NO: 19031-70-0
• Molecular Formula: C9H11F
• Molecular Weight: 138.185
• Mol File: 19031-70-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, (1-fluoropropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-fluoropropyl)-(19031-70-0)
• EPA Substance Registry System: Benzene, (1-fluoropropyl)-(19031-70-0)

Safety Data

• Hazardous Substances Data: 19031-70-0(Hazardous Substances Data)

Upstream product

• 93-54-9 1-Phenyl-1-propanol 
• 103-65-1 phenylpropane 
• 1821-12-1 4-Phenylbutyric acid 
• 90-27-7 2-Phenylbutyric acid 

Relevant articles and documents

Transition metal-free cross-dehydrogenative arylation of unactivated benzylic C-H bonds

The cross-dehydrogenative arylation of benzylic C-H bonds with arenes provides straightforward access to synthetically useful 1,1-diarylmethanes, from readily available starting materials. Current approaches suffer from limited substrate scope, requirement for large excesses of alkyl arene and/or non-trivial reaction set up. We report a transition metal-free cross-dehydrogenative arylation of benzylic C-H bonds using alkyl benzene derivatives and electron-rich arenes as coupling partners. The method proceeds through the in situ generation of a reactive benzyl fluoride intermediate which then reacts with the nucleophilic arene. The reaction tolerates a wide variety of functional groups including unprotected polar functionality and has been applied to the late-stage benzylation of several biologically relevant molecules.

Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process is described herein. This light-mediated, catalyst-free methodology is fast and broadly applicable allowing for the preparation of C?F bonds from (hetero)benzylic, propargylic, and non-activated tertiary alcohol derivatives. Preliminary mechanistic studies support that the key step of the reaction is the single-electron oxidation of cesium oxalates—which are readily available from the corresponding tertiary alcohols—with in situ generated TEDA2+. (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor.

Fluorodecarboxylation, rearrangement and cyclisation: the influence of structure and environment on the reactions of carboxylic acids with xenon difluoride

The reactions of structurally diverse carboxylic acids with XeF2 in both CH2Cl2/Pyrex and CH2Cl2/PTFE have been studied. Pyrex appears to be a very effective heterogeneous catalyst for an electrophilic mode of reaction of polarised XeF2, leading to rearrangement, cyclisation and cationic products. In CH2Cl2/PTFE, fluorodecarboxylation is the main mode of reaction, in accordance with previous studies, and may occur via a SET reaction of unpolarised XeF2.