1904-62-7Relevant articles and documents
Exceptional Substrate Diversity in Oxygenation Reactions Catalyzed by a Bis(μ-oxo) Copper Complex
Paul, Melanie,Teubner, Melissa,Grimm-Lebsanft, Benjamin,Golchert, Christiane,Meiners, Yannick,Senft, Laura,Keisers, Kristina,Liebh?user, Patricia,R?sener, Thomas,Biebl, Florian,Buchenau, S?ren,Naumova, Maria,Murzin, Vadim,Krug, Roxanne,Hoffmann, Alexander,Pietruszka, J?rg,Ivanovi?-Burmazovi?, Ivana,Rübhausen, Michael,Herres-Pawlis, Sonja
supporting information, p. 7556 - 7562 (2020/05/29)
The enzyme tyrosinase contains a reactive side-on peroxo dicopper(II) center as catalytically active species in C?H oxygenation reactions. The tyrosinase activity of the isomeric bis(μ-oxo) dicopper(III) form has been discussed controversially. The synthesis of bis(μ-oxo) dicopper(III) species [Cu2(μ-O)2(L1)2](X)2 ([O1](X)2, X=PF6?, BF4?, OTf?, ClO4?), stabilized by the new hybrid guanidine ligand 2-{2-((dimethylamino)methyl)phenyl}-1,1,3,3-tetramethylguanidine (L1), and its characterization by UV/Vis, Raman, and XAS spectroscopy, as well as cryo-UHR-ESI mass spectrometry, is described. We highlight selective oxygenation of a plethora of phenolic substrates mediated by [O1](PF6)2, which results in mono- and bicyclic quinones and provides an attractive strategy for designing new phenazines. The selectivity is predicted by using the Fukui function, which is hereby introduced into tyrosinase model chemistry. Our bioinspired catalysis harnesses molecular dioxygen for organic transformations and achieves a substrate diversity reaching far beyond the scope of the enzyme.
Selective butyrylcholine esterase inhibitor or pharmaceutically acceptable salt thereof, and preparation method and application thereof
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Paragraph 0044; 0047-0048, (2020/01/12)
The invention discloses a selective butyrylcholine esterase inhibitor represented by a general formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method and an application thereof. Butyrylcholine esterase inhibitory activity, sel
Hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines catalyzed by palladium-nickel bimetallic nanoparticles
Bao, Hailin,Wang, Dingsheng,Wang, Xinyan,Cheng, Chuanjie,Li, Yadong,Hu, Yuefei
, p. 47125 - 47130 (2015/06/16)
Since palladium-catalysts have strong abilities for both hydrogenation of nitro-group and hydrogenolysis of benzylamine, they have a much lower chemoselectivity for the hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes. In this article, component stable Pd-Ni bimetallic nanoparticles were prepared by simply heating RANEY-Ni and Na2PdCl4 together in water. They demonstrated novel synergistic effects when they were used as a bimetallic catalyst, by which a highly efficient and chemoselective hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines was achieved.