19081-61-9

Basic information

• Product Name: 1-(4-methylphenyl)-3-phenyl-1,2,4-triazol-5-one
• Synonyms: 1-(4-methylphenyl)-3-phenyl-1,2,4-triazol-5-one
• CAS NO: 19081-61-9
• Molecular Weight: 251.288
• Mol File: 19081-61-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-3-phenyl-1,2,4-triazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-3-phenyl-1,2,4-triazol-5-one(19081-61-9)
• EPA Substance Registry System: 1-(4-methylphenyl)-3-phenyl-1,2,4-triazol-5-one(19081-61-9)

Safety Data

• Hazardous Substances Data: 19081-61-9(Hazardous Substances Data)

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 65-85-0 benzoic acid 
• 917-61-3 sodium isocyanate 
• 49829-54-1 N-(p-tolyl)benzohydrazonoyl chloride 
• 108-73-6 3,5-dihydroxyphenol 
• 65763-66-8 1-Benzoyl-2-(4-methylphenyl)hydrazine 
• 939-07-1 3-phenyl-1,2,4-triazolin-5-one 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Facile access to a variety of 2,5-biaryl-1,2,4-TRIAZOL-3-ones via regioselective N-arylation of triazolones

A selective synthetic method of the 2,5-biaryltriazolones has been developed via copper-catalyzed N-arylation reaction. Aryltriazolones, which were readily prepared from commercially available compounds, were N-arylated to 2,5-biaryltriazolones with high regioselectivity. This approach allows for access to a variety of 2,5-biaryl-1,2,4-trizol-3-ones in a simple and practical manner.