19102-07-9

Basic information

• Product Name: 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE
• Synonyms: 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE;3,4-ETHYLENEDIOXYBENZONITRILE;BUTTPARK 96\04-14;1,4-Benzodioxane-6-carbonitrile;2,3-DIHYDRO-1,4-Benzodioxane-6-carbonitrile;1,4-Benzodioxan-6-carbonitrile;3-dihydrobenzo[b][1;4]dioxine-6-carbonitrile
• CAS NO: 19102-07-9
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Product Categories: Aromatic Nitriles
• Mol File: 19102-07-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 278.1 °C at 760 mmHg
• Flash Point: 119.2 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.00436mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE(19102-07-9)
• EPA Substance Registry System: 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONITRILE(19102-07-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 19102-07-9(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1,4-Benzodioxine-6-Carbonitrile is a chemical compound that belongs to the class of organic compounds known as benzodioxines. This chemical group is characterized by a benzene ring fused to a dioxine ring. 2,3-Dihydro-1,4-Benzodioxine-6-Carbonitrile is a less common compound, and little is known about its specific uses or properties to the general public. It contains a benzodioxinyl group, which implies that it might exhibit certain biological activities based on the presence of this bioactive moiety. Additional research could reveal more about its potential applications or hazards in industries like medicine or manufacturing.

InChI:InChI=1/C9H7NO2/c10-6-7-1-2-8-9(5-7)12-4-3-11-8/h1-2,5H,3-4H2

Upstream product

• 17345-61-8 3,4-dihydroxybenzonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 57744-67-9 6-iodo-1,4-benzodioxane 
• 77287-34-4 formamide 
• 31127-39-6 2,3-dihydrobenzo[b][1,4]dioxin-6-carbaldoxime 
• 52287-51-1 6-bromo-1,4-benzodioxane 
• 124-38-9 carbon dioxide 
• 6761-70-2 2,3-dihydro-1,4-benzodioxine-6-carbonyl chloride 
• 557-21-1 zinc(II) cyanide 
• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 7321-55-3 2,2-dimethylmalononitrile 
• 119072-55-8 tert-butylisonitrile 
• 33632-35-8 6-methyl-2,3-dihydrobenzo[b][1,4]dioxine 
• 17413-10-4 2,3-dihydro-1,4-benzodioxin-6-ylmethylamine 

Downstream Products

• 337508-71-1 2,3-dihydrobenzo[b][1,4]dioxine-6-carbothioamide 
• 299169-62-3 2H,3H-benzo[e]1,4-dioxane-6-carboxamide 
• 1260433-15-5 (3-bromophenyl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanimine 

Relevant articles and documents

One step of palladium catalyzed benzodioxane ring C-O bond formation, synthesis of isoamericanol A and isoamericanin A

A number of benzodioxane compounds were synthesized using the palladium-catalyzed etherification of aryl halides by employing triphenylphosphane ligands. This method was used as key step in the synthesis of two natural products isoamericanol A and isoamericanin A.

Zn-catalyzed cyanation of aryl iodides

We report the first example of zinc-catalyzed cyanation of aryl iodides with formamide as the cyanogen source. The transformation was promoted by the bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into nitrile products in good to excellent yields. This approach is an exceedingly simple and benign method for the synthesis of aryl nitriles and is likely to proceed via a dinuclear Zn-concerted catalysis.

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability. This journal is