191103-80-7

Basic information

• Product Name: 1-Trityl-1H-imidazole-4-carboxylic acid
• Synonyms: 1-Trityl-1H-imidazole-4-carboxylic acid;1-Tritylimidazole-3-carboxylic aicd;1-Trityl-1H-imidazole-4-carboxylic acid 1-Tritylimidazole-3-carboxylic aicd
• CAS NO: 191103-80-7
• Molecular Formula: C₂₃H₁₈N₂O₂
• Molecular Weight: 354.41
• Product Categories: blocks;Carboxes;Imidazoles
• Mol File: 191103-80-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 546.287 °C at 760 mmHg
• Flash Point: 284.184 °C
• Appearance: /
• Density: 1.165 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Trityl-1H-imidazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Trityl-1H-imidazole-4-carboxylic acid(191103-80-7)
• EPA Substance Registry System: 1-Trityl-1H-imidazole-4-carboxylic acid(191103-80-7)

Safety Data

• Hazardous Substances Data: 191103-80-7(Hazardous Substances Data)

Usage

Description

1-Trityl-1H-imidazole-4-carboxylic acid is an organic compound characterized by its trityl group and imidazole ring, which contributes to its unique chemical properties. It is a key intermediate in the synthesis of various biologically active molecules and has potential applications in the pharmaceutical industry due to its ability to form complex structures with other molecules.

Uses

Used in Pharmaceutical Industry:
1-Trityl-1H-imidazole-4-carboxylic acid is used as a reactant for the synthesis of spiro[indole-3,2''-pyrrolidin]-2(1H)-one based inhibitors. These inhibitors have potential applications in the development of new drugs targeting specific biological pathways, making them valuable in the treatment of various diseases and conditions.

Upstream product

• 53525-60-3 4-carbethoxy-1-triphenyl methyl-1H-imidazole 
• 76-83-5 trityl chloride 
• 76074-88-9 methyl 1-(triphenylmethyl)-1H-imidazole-4-carboxylate 
• 925-90-6 ethylmagnesium bromide 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 33769-07-2 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole 
• 1072-84-0 imidazole-4-carboxylic acid 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 

Downstream Products

• 637335-79-6 1-trityl-1H-imidazole-4-carboxylic acid (4-{[6-amino-1-butyl-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-amide 
• 1204738-80-6 1-trityl-1H-imidazole-4-carboxylic acid 4-[4-(3,3-dimethyl-butyryl)-3-hydroxy-2-trifluoromethyl-phenoxymethyl]-benzylamide 
• 1093255-30-1 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide 
• 1312309-05-9 C₃₅H₂₇F₃N₆O₂ 
• 1360553-19-0 C₃₉H₃₃N₇O 
• 1107062-18-9 C₄₀H₃₇N₃O₆S 
• 337969-56-9 (2S)-1-{[1-(triphenylmethyl)imidazol-4-yl]carbonyl}-3-(1,2,3,4-tetrahydroisoquinolyl)-N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]carboxamide 
• 337969-55-8 (2S)-1-{[1-(triphenylmethyl)imidazol-4-yl]carbonyl}-indolin-2-yl-N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]carboxamide 
• 337969-54-7 (2S)-1-[1-(triphenylmethyl)imidazol-4-yl]carbonyl-3-(1,2,3,4-tetrahydroisoquinolyl)-N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-hydroxy-1-(methylethyl)ethyl]carboxamide 
• 337969-53-6 (2S)-1-{[1-(triphenylmethyl)imidazol-4-yl]carbonyl}-indolin-2-yl-N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-hydroxy-1-(methylethyl)ethyl]carboxamide 
• 1027927-95-2 [2-(2-methoxy-ethyl)-4-(naphthalene-1-carbonyl)-piperazin-1-yl]-(1-trityl-1H-imidazol-4-yl)-methanone 

Relevant articles and documents

Intermediate for preparing medetomidine and its preparation method and use

The invention provides an intermediate for preparing medetomidine. The intermediate is a compound shown in the formula (I). The invention also provides a preparation method of the intermediate, and ause of the intermediate in the preparation of medetomidine. The compound shown in the formula (I) is used for preparation of medetomidine so that the raw material is cheap and easy to obtain, synthesis processes are simple, the reaction cycle is short, the environmental pollution is avoided, operation is simple, the harsh reaction conditions are avoided, the operation and post-treatment are simple, the yield and the product purity are high, the intermediate in each step is a solid and is easy to purify, a production cost is low, and the intermediate is suitable for industrial large-scale production and conforms to the principle of green chemistry.

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound 43 that exhibits remarkable antiviral activity (EC50 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species.

THIA-TRIAZA-CYCLOPENTAZULENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of general formula (1) wherein 5 R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and th