191155-81-4

Basic information

• Product Name: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL;2-(Trifluoromethyl)benzenepropanol;3-(2-Trifluoromethylphenyl)propanol
• CAS NO: 191155-81-4
• Molecular Formula: C₁₀H₁₁F₃O
• Molecular Weight: 204.1889496
• Mol File: 191155-81-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 235.271°C at 760 mmHg
• Flash Point: 104.09°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 0.028mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL(191155-81-4)
• EPA Substance Registry System: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL(191155-81-4)

Safety Data

• Hazardous Substances Data: 191155-81-4(Hazardous Substances Data)

Usage

Description

3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL, also known as 2-(Trifluoromethyl)benzenepropanol, is an organic compound characterized by its unique molecular structure featuring a trifluoromethyl group attached to a phenyl ring, which is connected to a propane unit with a hydroxyl group. 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL is known for its potential applications in chemical synthesis and pharmaceutical development due to its versatile functional groups and reactivity.

Uses

Used in Chemical Synthesis:
3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL is used as a synthetic intermediate for the preparation of various complex organic molecules. Its unique structure allows for a range of chemical reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL is used as a key component in the development of new drugs. Its ability to participate in a variety of chemical reactions, such as dearomatizing spirocyclization and aryl amination, enables the creation of novel molecular structures with potential therapeutic properties.
Used in Organic Chemistry Research:
3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL is also utilized in academic and industrial research settings to study the reactivity and properties of trifluoromethyl-substituted compounds. Its unique structure provides opportunities for exploring new reaction pathways and understanding the effects of trifluoromethyl groups on molecular behavior.

InChI:InChI=1/C10H11F3O/c11-10(12,13)9-6-2-1-4-8(9)5-3-7-14/h1-2,4,6,14H,3,5,7H2

Upstream product

• 94022-99-8 3-(2-(trifluoromethyl)phenyl)propanoic acid 
• 191155-80-3 3-(2-(trifluoromethyl)phenyl)propanoic acid ethyl ester 

Downstream Products

• 376641-58-6 3-(2-(trifluoromethyl)phenyl)propanal 
• 165803-43-0 1-(3-bromopropyl)-2-trifluoromethylbenzene 
• 123486-66-8 3-<2'-(trifluoromethyl)phenyl>-2-propenal 

Relevant articles and documents

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

DIRECT C-H AMINATION AND AZA-ANNULATION

In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.