191220-25-4

Basic information

• Product Name: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-chlorophenyl)-
• CAS NO: 191220-25-4
• Molecular Formula: C13H9Cl2NO
• Molecular Weight: 266.127
• Mol File: 191220-25-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-chlorophenyl)-(191220-25-4)
• EPA Substance Registry System: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-chlorophenyl)-(191220-25-4)

Safety Data

• Hazardous Substances Data: 191220-25-4(Hazardous Substances Data)

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 30529-70-5 2-chloro-6-methyl nicotinic acid 

Downstream Products

• 191220-29-8 3-(3-chlorobenzoyl)-N-ethyl-6-methylpyridin-2-amine 
• 178548-58-8 YM-976 
• 178548-55-5 4-(3-chloro-phenyl)-1-ethyl-7-methyl-1H-[1,8]naphthyridin-2-one 

Relevant articles and documents

Synthetic studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1,8-naphthyridin-2(1H)-one derivatives.

In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1,8-naphthyridin-2(1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure-activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived from human peripheral blood cells and no effect on the other PDE types (1, 2, 3, 5). The inhibition of the tumor necrosis factor-alpha (TNF-alpha) release in vitro and the carrageenan-induced pleurisy in rats were also described.