191327-28-3

Basic information

• Product Name: (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER
• Synonyms: 3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER;METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3(R)-CARBOXYLATE;(R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER;(R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester, (3R)-;(R)-Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• CAS NO: 191327-28-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 191327-28-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 298°C at 760 mmHg
• Flash Point: 134.1°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.65±0.40(Predicted)
• CAS DataBase Reference: (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER(191327-28-3)
• EPA Substance Registry System: (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER(191327-28-3)

Safety Data

• Hazardous Substances Data: 191327-28-3(Hazardous Substances Data)

Usage

General Description

"(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid methyl ester" is a chemical compound that belongs to the family of isoquinoline alkaloids. It is a methyl ester derivative of tetrahydroisoquinoline carboxylic acid and exists as a white solid at room temperature. (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER has potential biological activities and is associated with a variety of pharmacological effects, including analgesic, anti-inflammatory, and neuroprotective properties. It is also being studied for its potential use in the treatment of Parkinson's disease and other neurological disorders. Additionally, it has been investigated for its potential as a building block in the synthesis of other pharmaceutical compounds.

InChI:InChI=1/C11H13NO2/c1-14-11(13)10-6-8-4-2-3-5-9(8)7-12-10/h2-5,10,12H,6-7H2,1H3

Upstream product

• 103733-65-9 (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 78879-20-6 D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid 
• 312639-49-9 N-Boc-(D)-Tic methyl ester 

Relevant articles and documents

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective σ1 ligands. Part 1

Herein is described a new class of selective σ1 ligands consisting of tetrahydroisoquinoline-hydantoin (Tic-hydantoin) derivatives. Compound 3a has high affinity (IC50 = 16 nM) for the σ1 receptor and is selective in a large panel of therapeutic targets. This first study presents structural changes around the Tic-hydantoin core, leading to a Tic-hydantoin analogue with a higher σ1 affinity (IC50 ≈ 1 nM).