191348-14-8

Basic information

• Product Name: 2-IODO-4-METHOXYPHENYLAMINE
• Synonyms: 4-AMino-3-iodoanisole[2-Iodo-4-Methoxyaniline];4-Methoxy-2-iodoaniline;2-IODO-4-METHOXYPHENYLAMINE;2-iodo-4-methoxyaniline;4-Amino-3-iodoanisole
• CAS NO: 191348-14-8
• Molecular Formula: C₇H₈INO
• Molecular Weight: 249.05
• Product Categories: pharmacetical
• Mol File: 191348-14-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 304.986 °C at 760 mmHg
• Flash Point: 138.251 °C
• Appearance: brown liquid
• Density: 1.807 g/cm³
• Vapor Pressure: 0.000845mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: 2-IODO-4-METHOXYPHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-4-METHOXYPHENYLAMINE(191348-14-8)
• EPA Substance Registry System: 2-IODO-4-METHOXYPHENYLAMINE(191348-14-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 191348-14-8(Hazardous Substances Data)

Usage

Chemical Properties

Brown liqui

InChI:InChI=1/C7H8INO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 214279-40-0 3-iodo-4-nitroanisol 
• 766-85-8 3-methoxy-1-iodobenzene 
• 104-94-9 4-methoxy-aniline 
• 18437-68-8 tert-butyl N-(4-methoxyphenyl)carbamate 
• 626-02-8 3-Iodophenol 
• 66416-73-7 p-hydroxy-o-iodoaniline 
• 74-88-4 methyl iodide 
• 157496-75-8 tert-butyl (2-iodo-4-methoxyphenyl)carbamate 

Downstream Products

• 627086-06-0 N-(2-iodo-4-methoxyphenyl)methanesulfonamide 
• 945676-31-3 N-(2-iodo-4-methoxyphenyl)-4-methoxybenzamide 
• 769921-94-0 4-methoxy-2-(1,3-thiazol-2-yl)aniline 
• 959698-81-8 methyl 3-[N-(2-iodo-4-methoxyphenyl)amino]-2,2-dimethylpropionate 
• 959698-56-7 methyl 3-[N-(2-iodo-4-methoxyphenyl)amino]propionate 
• 157496-75-8 tert-butyl (2-iodo-4-methoxyphenyl)carbamate 
• 1072123-55-7 2-(hex-1-yn-1-yl)-4-methoxyaniline 
• 1426138-87-5 C₃₂H₂₆N₄O₅S 
• 1314595-90-8 N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide 
• 1436750-46-7 1-[4-methoxy-2-(buta-1,3-diynyl)phenyl]urea 
• 1436752-61-2 4-methoxy-2-[4-(trimethylsilyl)buta-1,3-diynyl]aniline 
• 77093-88-0 7-methoxy-2-phenylquinoxaline 
• 1609244-29-2 C₁₉H₁₉NO₂ 
• 1616974-98-1 N-(2-ethynyl-4-methoxyphenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Modular counter-Fischer?indole synthesis through radical-enolate coupling

A single-electron transfer mediated modular indole formation reaction from a 2-iodoaniline derivative and a ketone has been developed. This transition-metal-free reaction shows a broad substrate scope and unconventional regioselectivity trends. Moreover, important functional groups for further transformation are tolerated under the reaction conditions. Density functional theory studies reveal that the reaction proceeds by metal coordination, which converts a disfavored 5-endo-trig cyclization to an accessible 7-endo-trig process.

Synthesis of carbazoles based on gold-copper tandem catalysis

An efficient synthetic method for carbazoles has been developed employing diazo anilinoalkynes as substrates. Sequential activation of the orthogonal functional groups embedded in diazo anilinoalkyne substrates by tandem gold-copper catalysis leads to the formation of highly substituted carbazoles. Substrate scope reveals a broad tolerability toward the substitution on aryl groups.

One-Pot Access to Benzo[a]carbazoles via Palladium(II)-Catalyzed Hetero- and Carboannulations

A Pd(II)-catalyzed direct synthesis of benzo[a]carbazoles has been achieved through aminopalladation of alkynes, followed by intramolecular nucleophilic addition of the generated carbon-palladium bond to a tethered cyano/aldehyde group. Compared to literature procedures, this synthetic approach is operationally simple, uses simple substrates, and offers a fast intramolecular assembly resulting in the direct synthesis of benzo[a]carbazoles in which a wide variation of substituents at different sites is well-tolerated, leaving enough opportunity for diversification.