19146-51-1

Basic information

• Product Name: Butanoic acid, 2-(acetylamino)-,(2S)-
• Synonyms: Butanoic acid, 2-(acetylamino)-,(S)-; Butyric acid, 2-acetamido-, (S)-(-)- (8CI); (S)-(-)-a-Acetamidobutyric acid; N-Acetyl-L-a-aminobutyric acid
• CAS NO: 19146-51-1
• Molecular Formula: C6H11 N O3
• Molecular Weight: 145.158
• Mol File: 19146-51-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-(acetylamino)-,(2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-(acetylamino)-,(2S)-(19146-51-1)
• EPA Substance Registry System: Butanoic acid, 2-(acetylamino)-,(2S)-(19146-51-1)

Safety Data

• Hazardous Substances Data: 19146-51-1(Hazardous Substances Data)

Upstream product

• 1492-24-6 L-2-aminobutyric acid 
• 108-24-7 acetic anhydride 
• 50285-36-4 N-(1-Ethyl-2-propinyl)acetamid 
• 20306-86-9 (S)-N-(1-phenylpropyl)acetamide 
• 62973-41-5 2-(N-Acetylamino-)-buttersaeureethylester 
• 65499-61-8 (Z)-α-N-acetylamino-2-butenoic acid 

Downstream Products

• 997-55-7 N-Acetyl-L-aspartic acid 

Relevant articles and documents

Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres

Hepsin is a type II transmembrane serine protease (TTSP) associated with cell proliferation and overexpressed in several types of cancer including prostate cancer (PCa). Because of its significant role in cancer progression and metastasis, hepsin is an attractive protein as a potential therapeutic and diagnostic biomarker for PCa. Based on the reported Leu-Arg dipeptide-based hepsin inhibitors, we performed structural modification and determined in vitro hepsin- and matriptase-inhibitory activities. Comprehensive structure-activity relationship studies identified that the p-guanidinophenylalanine-based dipeptide analog 22a exhibited a strong hepsin-inhibitory activity (Ki = 50.5 nM) and 22-fold hepsin selectivity over matriptase. Compound 22a could be a prototype molecule for structural optimization of dipeptide-based hepsin inhibitors.

ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST - II. ESTERS OF N-ACETYL AMINO ACIDS

D-N-Acetyl amino acid esters were obtained via enantioselective hydrolysis of their racemates by use of fermenting yeast.Evidence is given that proteinases are the enzymes involved.

ASYMMETRISCHE KATALYSEN. XXX. ENANTIOSELEKTIVE HYDRIERUNG VON CROTONSAEUREDERIVATEN MIT RHODIUM-PHOSPHIN-KATALYSATOREN

The Z- and E-isomers of the α-N-benzoylamino-2-butenoic acid methyl ester, the E/Z mixtures of α-N-benzoylamino-2-butenoic acid, and the Z-form of α-N-acetylamino-2-butenoic acid were hydrogenated enantioselectively.The hydrogenation products are derivatives of α-aminobutyric acid, which can be reduced to aminobutanol, the optically active component of the antituberculosis drug (+)-ethambutol.In situ catalysts consisting of 2 and the optically active phosphine ligands (+)- and (-)-Norphos, (+)-Prophos, (-)-Chiraphos, (-)-BPPFA, (-)-Diop, and (+)- and (-)-CpMn(CO)2diop were used.The best results were obtained with the substrate (Z)-α-acetylamino-2-butenoic acid and the catalyst 2/(-)-Norphos with 91.5percent e.e.