1914946-33-0

Basic information

• Product Name: ethyl 5-bromoisoxazole-3-carboxylate
• CAS NO: 1914946-33-0
• Molecular Weight: 220.023
• Mol File: 1914946-33-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 5-bromoisoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-bromoisoxazole-3-carboxylate(1914946-33-0)
• EPA Substance Registry System: ethyl 5-bromoisoxazole-3-carboxylate(1914946-33-0)

Safety Data

• Hazardous Substances Data: 1914946-33-0(Hazardous Substances Data)

Upstream product

• 126085-91-4 5-tributylstannanyl-isoxazole-3-carboxylic acid ethyl ester 
• 70432-25-6 methyl 5-oxo-4,5-dihydroisoxazole-3-carboxylate 
• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 

Relevant articles and documents

Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction

The existence of multidrug-resistant influenza viruses, coupled with the continuously antigenic shift and antigenic drift of influenza viruses, necessitates the development of the next-generation of influenza antivirals. As the AM2-S31N mutant persists in more than 95% of current circulating influenza A viruses, targeting the AM2-S31N proton channel appears to be a logical and valid approach to combating drug resistance. Starting from compound 1, an isoxazole compound with potent AM2-S31N channel blockage and antiviral activity, in this study we report an expeditious synthetic strategy that allows us to promptly explore the structure-activity relationships of isoxazole-containing AM2-S31N inhibitors. Propelled by the convenient synthesis, the lead optimization effort yielded a number of potent antivirals with submicromolar efficacy against several human clinical isolates of influenza A viruses, including both oseltamivir-sensitive and -resistant strains.