1915-98-6Relevant articles and documents
Synthesis and solid-phase application of a 9-xanthenyl handle
Somlai, Csaba,Hegyes, Peter,Fenyoe, Robert,Toth, Gabor K.,Penke, Botond,Voelter, Wolfgang
, p. 526 - 532 (2001)
The acid-labile 5-[(9-aminoxanthen-2-yl)oxy]valeric acid was prepared in a six-step route. The usefulness of the resulting handle was investigated with solid-phase peptide synthesis of cholecystokinin-8 sulfate and the phosphorylated fragment of the ζ-sub
REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION
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Page/Page column 109; 110, (2020/06/01)
Thianthrene derivative of the Formula (I): wherein R1 to R8 may be the same or different and are selected from hydrogen, Cl, F, a partially or fully fluorinated C1 to C6 alkyl group, and wherein n is 0 or 1, with the proviso that at least one of R1 to R8 is not hydrogen and process for C-H functionalization of aromatic compounds using this compound.
Site-Selective C?H Oxygenation via Aryl Sulfonium Salts
Sang, Ruocheng,Korkis, Stamatis E.,Su, Wanqi,Ye, Fei,Engl, Pascal S.,Berger, Florian,Ritter, Tobias
supporting information, p. 16161 - 16166 (2019/11/03)
Herein, we report a two-step process forming arene C?O bonds in excellent site-selectivity at a late-stage. The C?O bond formation is achieved by selective introduction of a thianthrenium group, which is then converted into C?O bonds using photoredox chemistry. Electron-rich, -poor and -neutral arenes as well as complex drug-like small molecules are successfully transformed into both phenols and various ethers. The sequence differs conceptually from all previous arene oxygenation reactions in that oxygen functionality can be incorporated into complex small molecules at a late stage site-selectively, which has not been shown via aryl halides.