19152-38-6Relevant articles and documents
Synthesis and antidyslipidemic activity of chalcone fibrates
Shukla, Poonam,Srivastava, Swayam P.,Srivastava, Rohit,Rawat, Arun K.,Srivastava, Arvind K.,Pratap, Ram
, p. 3475 - 3478 (2011)
A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c an
Synthesis, characterization, antimicrobial activities, and structural studies of Lanthanide (III) complexes with 1-(4-Chlorophenyl)-3-(4-fluoro/ hydroxyphenyl)prop-2-en-1-thiosemicarbazone
Oza, Chandra K.,Jain, Meenakshi,Jain, Neelima,Verma, Dinesh
, p. 377 - 386 (2010)
Twelve coordinate lanthanide (III) complexes with the general composition [Ln L3Xn(H2O)n] where Ln = Pr(III), Sm(III), Eu (III), Gd (III), Tb (III), Dy (III), X = Cl-1, NO3 -2, n = 2-7, and
Charge transfer based "turn-on" chemosensor for Zn2 + ion recognition using new triaryl pyrazoline derivative
Jeyanthi, Dharmaraj,Iniya, Murugan,Krishnaveni, Karuppiah,Chellappa, Duraisamy
, p. 231 - 237 (2016)
The fluoroionophore PY serves as a selective and fluorimetric chemosensor for Zn2 + based on charge transfer (CT). A mechanism for the binding mode was proposed based on fluorescence changes, NMR experiments and theoretical calculations. The 1:
Synthesis, Crystal Structure, Biological Evaluation, DFT Calculations and Third Order Nonlinear Optical Studies of Pyrazolines
Gaonkar, Santosh L.,Hari, Gangadhar,Lokanath, N. K.,Naraharisetty, Sri Ram G,Nayak, Swarnagowri,Pai, K. S. R.,Parol, Vinay,Sinha, Rajeev K.
, (2021/06/15)
Novel pyrazoline derivatives were synthesized and characterized by FTIR, NMR, UV-visible, and mass spectral studies. All the synthesized compounds 6a-f were screened for anticancer activity against MCF-7 and HCT 116 cell lines via SRB assay. Among the synthesized pyrazolines 6b and 6f showed appreciable anticancer activity. The molecular docking study was done with two proteins (PDB No: 1M17 and 5ZTO) to study the binding interactions of the compounds with proteins. ADME study showed that the compounds exhibited drug-likeness properties, following Lipinski's rule of five. The molecular structure of compound 6b was studied using the single-crystal X-ray diffraction method. The structural, absorption and first static hyperpolarizability properties of the compound 6b were studied using density functional theory (DFT) calculations. The experimental data and calculated FTIR and UV-visible spectral data are in good agreement. The third order nonlinear optical properties were studied using open and closed aperture z-scan techniques. The compound 6b showed nonlinear absorption(β) of 1.94×10?11m/W at intensity (I0) is 4.49GW/cm2. Third order nonlinear susceptibility is of the order of 10?12 esu and this indicates the molecule has the potential to be used in nonlinear optical device applications.
New chalcone derivatives: Synthesis, antiviral activity and mechanism of action
Fu, Yun,Gan, Xiuhai,Hu, Deyu,Liu, Dan,Ren, Xiaoli,Song, Baoan,Zeng, Huanan
, p. 24483 - 24490 (2020/07/15)
In this work, twenty-eight chalcone derivatives containing a purine (sulfur) ether moiety were synthesized and their antiviral activities were evaluated. Biological results showed that compound 5d exhibited outstanding inactive activity against tobacco mosaic virus (TMV) in vivo (EC50 = 65.8 μg mL-1), which is significantly superior to that of ribavirin (EC50 = 154.3 μg mL-1). Transmission electron microscopy indicated that compound 5d can break the integrity of TMV particles. The results of microscale thermophoresis, fluorescence titration and molecular docking showed that compound 5d had stronger combining affinity (Ka = 1.02 ×105 L mol-1, Kd = 13.4 μmol L-1) with TMV coat protein (TMV-CP), which is due to the formation of five hydrogen bonds between compound 5d and the amino-acid residues of TMV-CP. These findings revealed that compound 5d can effectively inhibit the infective ability of TMV. This work provides inspiration and reference for the discovery of new antiviral agents.