191610-56-7

Basic information

• Product Name: (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid
• Synonyms: (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid
• CAS NO: 191610-56-7
• Molecular Weight: 419.475
• Mol File: 191610-56-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid(191610-56-7)
• EPA Substance Registry System: (2S,3R)-1-tert-butoxycarbonyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid(191610-56-7)

Safety Data

• Hazardous Substances Data: 191610-56-7(Hazardous Substances Data)

Upstream product

• 191610-54-5 (4R,5S)-1-tert-butoxycarbonyl-5-tert-butyldiphenylsiloxymethyl-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidine-2-one 
• 138509-45-2 4-bromo-2-cyclopentyloxyanisole 
• 90-05-1 2-methoxy-phenol 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 137-43-9 Cyclopentyl bromide 
• 191610-55-6 (4R,5S)-1-tert-butoxycarbonyl-4-(3-cyclopentyloxy-4-methoxyphenyl)-5-hydroxymethylpyrrolidin-2-one 
• 531-37-3 2-methoxyphenyl benzoate 

Downstream Products

• 85416-75-7 (R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 

Relevant articles and documents

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid

A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.