191613-95-3

Basic information

• Product Name: 2S-Cyclopentyl-3R-[2,2-dimethyl-1 S-(methylcarbamoyl)propylcarbamoyl]-5-methyl-hex-5-enoic acid benzyl ester
• CAS NO: 191613-95-3
• Molecular Weight: 456.626
• Mol File: 191613-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2S-Cyclopentyl-3R-[2,2-dimethyl-1 S-(methylcarbamoyl)propylcarbamoyl]-5-methyl-hex-5-enoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2S-Cyclopentyl-3R-[2,2-dimethyl-1 S-(methylcarbamoyl)propylcarbamoyl]-5-methyl-hex-5-enoic acid benzyl ester(191613-95-3)
• EPA Substance Registry System: 2S-Cyclopentyl-3R-[2,2-dimethyl-1 S-(methylcarbamoyl)propylcarbamoyl]-5-methyl-hex-5-enoic acid benzyl ester(191613-95-3)

Safety Data

• Hazardous Substances Data: 191613-95-3(Hazardous Substances Data)

Upstream product

• 89226-12-0 (S)-2-amino-N,3,3-trimethylbutanamide 
• 216578-59-5 (2S,3R)-2-Cyclopentyl-3-(2-methyl-allyl)-succinic acid 1-benzyl ester 

Relevant articles and documents

The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement

Matrix metalloproteinase inhibitors of general formula (1) were synthesised by a route involving an Ireland-Claisen rearrangement which enables systematic modification of the substituent alpha to the hydroxamic acid. An analogue (12c) possessing an α-cyclopentyl group is a potent broad spectrum inhibitor that displays high and sustained blood levels following oral dosing in both the rat and marmoset ex-vivo bioassays. This compound and analogues are also potent inhibitors of TNFα release.