19163-21-4

Basic information

• Product Name: 5-PHENYL-2-THIOPHENECARBALDEHYDE
• Synonyms: 5-PHENYL-2-THIOPHENECARBOXALDEHYD&;5-phenylthiophene-2-carboxaldehyde;5-phenyl-2-thiophenecarbaldehyde, 90+%;5-Phenylthiophene-2-carboxaldehyde 98%;AKOS BAR-0518;5-PHENYL-2-THIOPHENECARBALDEHYDE;5-PHENYL-2-THIOPHENECARBOXALDEHYDE;5-PHENYLTHIOPHENE-2-CARBALDEHYDE
• CAS NO: 19163-21-4
• Molecular Formula: C₁₁H₈OS
• Molecular Weight: 188.25
• Product Categories: Carbonyl Compounds;Heterocycles;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiophenes
• Mol File: 19163-21-4.mol
• Article Data: 71

Chemical Properties

• Melting Point: 92-95 °C(lit.)
• Boiling Point: 340 °C at 760 mmHg
• Flash Point: 127 °C
• Appearance: /
• Density: 1.207 g/cm³
• Vapor Pressure: 8.84E-05mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-PHENYL-2-THIOPHENECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-2-THIOPHENECARBALDEHYDE(19163-21-4)
• EPA Substance Registry System: 5-PHENYL-2-THIOPHENECARBALDEHYDE(19163-21-4)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19163-21-4(Hazardous Substances Data)

Usage

General Description

5-Phenyl-2-thiophenecarbaldehyde is a chemical compound with the molecular formula C12H8OS. It is a yellow crystalline solid that is soluble in organic solvents such as chloroform and ether. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5-PHENYL-2-THIOPHENECARBALDEHYDE has a strong odor and is known for its aromatic and pungent smell. It is also used in organic synthesis as a building block for various organic compounds. Additionally, 5-Phenyl-2-thiophenecarbaldehyde has been studied for its potential biological and pharmacological activities.

InChI:InChI=1/C11H8OS/c12-8-10-6-7-11(13-10)9-4-2-1-3-5-9/h1-8H

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 591-50-4 iodobenzene 
• 497-19-8 sodium carbonate 
• 98-80-6 phenylboronic acid 
• 7283-96-7 5-Chloro-2-thiophenecarboxaldehyde 
• 780-69-8 triethoxyphenylsilane 
• 13116-27-3 4-iodophenylhydrazine 
• 98-03-3 thiophene-2-carbaldehyde 
• 5370-19-4 5-iodothiophene-2-carbaldehyde 
• 71-43-2 benzene 
• 825-55-8 2-phenylthiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 108-86-1 bromobenzene 

Downstream Products

• 58267-95-1 trans-3-(5-phenyl-2-thienyl)acrylic acid 
• 855300-93-5 (Z)-2-Benzoylamino-3-(5-phenyl-thiophen-2-yl)-acrylic acid methyl ester 
• 894779-29-4 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylic acid ethyl ester 
• 894779-41-0 4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde 
• 894779-36-3 4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carboxylic acid ethyl ester 
• 825-55-8 2-phenylthiophene 
• 771564-33-1 2-dicyanovinyl-5-phenylthiophene 
• 696662-07-4 (S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid 
• 696661-77-5 ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate 
• 1310430-87-5 C₁₅H₁₂ClNOS 
• 1310430-91-1 C₁₆H₁₂N₂OS 
• 1310430-94-4 C₁₇H₁₅NO₃S 
• 1310430-96-6 C₁₆H₁₅NO₂S 
• 1310430-98-8 C₁₇H₁₇NO₄S₂ 

Relevant articles and documents

Direct thiophene arylation catalysed by palladium

Direct thiophene arylation using a Heck-type reaction with Pd(OAc)2/NBu4Br as catalytic system is reported. Reactions with 2- and 3-substituted thiophenes have shown that substituent nature and position influence the cross-coupling.

Ratiometric luminescent molecular oxygen sensors based on uni-luminophores of CN Pt(II)(acac) complexes that show intense visible-light absorption and balanced fluorescence/phosphorescence dual emission

Uni-luminophores of CN cyclometalated Pt(ii) complexes with balanced room temperature fluorescence/phosphorescence dual emission were prepared for ratiometric oxygen sensing in both intensity mode and lifetime mode.

Synthesis of meso-tetraarylthienylporphyrins by Suzuki-Miyaura cross-coupling reaction and studying their UV-Vis absorption spectra

meso-Tetra(5-arylthien-2-yl)porphyrins and their copper complexes were synthesized by two different approaches using Suzuki-Miyaura cross-coupling reactions. The first, involving the formation of 5-arylthien-2-yl carbaldehydes, followed by condensation with pyrrole. The second is a direct process that involves the coupling of meso-tetra (5-bromothien-2-yl) porphyrins with the arylboronic acids. The yield of the second approach (40-50 %) was higher than the first approach (28-35 %). The UV-Vis absorption spectra of the synthesized porphyrins revealed bathochromic shifts when compared with the parent porphyrin. Additionally, the products showed no aggregation behaviour in solution (DCM), giving a linear correlation between absorption intensity and the concentration.

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

As the continuous rise in the incidence of antibiotic resistance, it is urgent to develop novel chemical scaffolds with antibacterial activities to control the spread of resistance to conventional antibiotics. In this study, a series of phenylthiazole and

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.