191936-91-1 Usage
Description
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH, also known as HIV-1 Tat protein, is an 11kDa protein derived from the HIV-1 virus. It plays a crucial role in the regulation of HIV-1 gene expression at the transcriptional and translational levels. The protein is located in the nucleus of infected cells and functions as a transcriptional activator, promoting the synthesis of full-length viral RNA and inducing RNA splicing. Its unique structure, with a series of amino acids including tyrosine, glycine, arginine, and lysine, allows it to specifically recognize and bind to the trans activator response element (TAR) from the HIV-1 RNA molecule.
Uses
Used in Antiviral Applications:
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH is used as an antiviral agent for targeting the HIV-1 virus. Its ability to bind to the TAR element in the HIV-1 RNA molecule makes it a potential therapeutic candidate for disrupting the virus's replication process and inhibiting the progression of the disease.
Used in Drug Delivery Systems:
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH can be employed in drug delivery systems to improve the targeting and efficacy of antiviral drugs against HIV-1. By conjugating the Tat protein with antiviral agents, it may be possible to enhance the delivery of these drugs to the infected cells, increasing their bioavailability and therapeutic outcomes.
Used in Research and Development:
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH serves as an important research tool for understanding the molecular mechanisms underlying HIV-1 replication and pathogenesis. Studying the interactions between the Tat protein and the TAR element can provide valuable insights into the development of novel antiviral strategies and therapeutic approaches for HIV-1 infection.
Used in Diagnostic Applications:
The HIV-1 Tat protein can be utilized in the development of diagnostic tools for detecting the presence of HIV-1 in patients. By designing assays that specifically recognize the Tat protein or its interaction with the TAR element, it may be possible to create sensitive and specific diagnostic tests for HIV-1 infection.
Used in Vaccine Development:
H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH may also play a role in the development of vaccines against HIV-1. Understanding the structure and function of the Tat protein can help researchers design immunogens that elicit protective immune responses against the virus, potentially leading to the development of effective vaccines.
Biochem/physiol Actions
Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.
Check Digit Verification of cas no
The CAS Registry Mumber 191936-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,9,3 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 191936-91:
(8*1)+(7*9)+(6*1)+(5*9)+(4*3)+(3*6)+(2*9)+(1*1)=171
171 % 10 = 1
So 191936-91-1 is a valid CAS Registry Number.
191936-91-1Relevant articles and documents
Selective binding of TAR RNA by a Tat-derived β-peptide
Gelman, Michael A.,Richter, Sara,Cao, Hong,Umezawa, Naoki,Gellman, Samuel H.,Rana, Tariq M.
, p. 3563 - 3565 (2003)
(Equation presented) The interaction between the HIV-1 Tat protein and the TAR RNA element in the nascent viral genomic transcript is required for viral replication. An 11-residue β-peptide (1), an all-β homologue of the Arg-rich region Tat 47-57, binds T
