192047-43-1

Basic information

• Product Name: (2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol
• Synonyms: (2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol
• CAS NO: 192047-43-1
• Molecular Weight: 562.91
• Mol File: 192047-43-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol(192047-43-1)
• EPA Substance Registry System: (2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol(192047-43-1)

Safety Data

• Hazardous Substances Data: 192047-43-1(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 392230-13-6 (2R)-1-benzyloxy-3-[1,3]dithian-2-yl-propan-2-ol 
• 14618-80-5 (R)-benzyl glycidol 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 192047-48-6 (1R)-(1-benzyloxymethyl-2-[1,3]dithian-2-yl-ethoxy)-tert-butyl-dimethyl-silane 
• 95452-06-5 tert-butyl(1,3-dithian-2-yl)dimethylsilane 
• 195257-60-4 (2S)-2-[2-(p-methoxybenzyloxy)ethyl]oxirane 

Downstream Products

• 392230-14-7 2,2-bis-[(2R,2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithiane 
• 392230-15-8 (2R,6R)-1,7-bis-benzyloxy-2,4,6-tris-(tert-butyl-dimethyl-silanyloxy)-heptane 
• 392230-23-8 (2R,6R)-1,7-Bis-benzyloxy-2,6-bis-(tert-butyl-dimethyl-silanyloxy)-heptan-4-one 

Relevant articles and documents

Multicomponent linchpin couplings of silyl dithianes via solvent- controlled brook rearrangement [4]

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Diastereoselective synthesis of 2,3,5-trisubstituted tetrahydrofurans via cyclofunctionalization reactions. Evidence of stereoelectronic effects

The work described herein considers the impact of stereoelectronic effects and allylic 1,3-strain in controlling the cyclofunctionalization reaction when a hydroxyl group is at the allylic position. The stereoelectronic arguments are supported by independent iodocyclization reactions performed using two secondary alcohols. The transition-state pathways involved in these reactions are established through a comparison of relative reaction rates. A bi-directional approach is used to demonstrate the potential of the iodocyclization reaction to differentiate a terminus in molecules with a pseudo C2 axis of symmetry, showing that two-directional synthesis can be used to differentiate between alternative transition-state pathways.