1921-70-6 Usage
Chemical Properties
colourless liquid
Uses
Different sources of media describe the Uses of 1921-70-6 differently. You can refer to the following data:
1. Lubricant; transformer oil. Anti-corrosion agent. Biological marker. In experimental systems to induce plasmacytomas; in production of monoclonal antibodies.
2. Pristane is a hydrocarbon oil adjuvant.
3. Pristane has been used as an inflammation-inducing agent, leading to myeloma development in BALB/c strain mice. It has been used as a rheumatoid arthritis-inducing agent in rats.
Definition
ChEBI: A norterpene that is an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group.
General Description
Pristane is a natural saturated terpenoid alkane used in research on the pathogenesis of autoimmune diseases such as arthritis and lupus.
Biochem/physiol Actions
Pristane is a hydrocarbon oil adjuvant widely used to induce tumorigenesis in mice and arthritis and lupus nephritis in rats. It works as a adjuvant for monoclonal antibody generation in mouse ascites.
Purification Methods
Purify pristane by shaking it with conc H2SO4 (care, if amount of pristane is too small then it should be diluted with pet ether not Et2O which is quite soluble H2SO4), then H2O (care, as it may heat up in contact with conc H2SO4), dry (MgSO4), evaporate and distil it over Na. [S.rensen & S.rensen Acta Chem Scand 3 939 1949, Beilstein 1 III 570.]
Check Digit Verification of cas no
The CAS Registry Mumber 1921-70-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,2 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1921-70:
(6*1)+(5*9)+(4*2)+(3*1)+(2*7)+(1*0)=76
76 % 10 = 6
So 1921-70-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H40/c1-16(2)10-7-12-18(5)14-9-15-19(6)13-8-11-17(3)4/h16-19H,7-15H2,1-6H3
1921-70-6Relevant articles and documents
Jain,Striha
, p. 4359 (1969)
Greener synthesis of pristane by flow dehydrative hydrogenation of allylic alcohol using a packed-bed reactor charged by pd/c as a single catalyst
Fukuyama, Takahide,Furuta, Akihiro,Hirobe, Yuki,Hyodo, Mamoru,Kasakado, Takayoshi,Ryu, Ilhyong
, (2021/10/05)
Our previous work established a continuous-flow synthesis of pristane, which is a saturated branched alkane obtained from a Basking Shark. The dehydration of an allylic alcohol that is the key to a tetraene was carried out using a packed-bed reactor charged by an acid–silica catalyst (HO-SAS) and flow hydrogenation using molecular hydrogen via a Pd/C catalyst followed. The present work relies on the additional propensity of Pd/C to serve as an acid catalyst, which allows us to perform a flow synthesis of pristane from the aforementioned key allylic alcohol in the presence of molecular hydrogen using Pd/C as a single catalyst, which is applied to both dehydration and hydrogenation. The present one-column-two-reaction-flow system could eliminate the use of an acid catalyst such as HO-SAS and lead to a significant simplification of the production process.
A method for synthesizing basking shark alkane
-
, (2017/08/23)
The present invention discloses a novel method for chemically synthesizing pristane with isophytol as a starting material. Isophytol is used, and pristane is prepared through oxidation, a methyl Grignard reaction, sulfonylation, halogenation and reduction. The method in the present invention, as compared with the conventional synthesizing method, adopts cheap raw materials, avoids high pressure hydrogenation reactions, and solves the problems of methyl migration caused by a dehydration reaction or isomerization caused by cyclization in the conventional synthesizing method. The method of the present invention is suitable for industrial production of pristane.
