192182-56-2 Usage
Description
4-Isoquinolineboronic acid is a pink solid that serves as a versatile chemical intermediate and reagent in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
4-Isoquinolineboronic acid is used as a reactant for the preparation of selective steroid-11β-hydroxylase (CYP11B1) inhibitors, which are crucial for the treatment of cortisol-dependent diseases.
Used in Organic Synthesis:
4-Isoquinolineboronic acid is used as a reactant for the preparation of tetrabutylammonium trifluoroborates, which are useful in various organic synthesis processes.
Used in Medicinal Chemistry:
4-Isoquinolineboronic acid is used as a reactant for the synthesis of heteroaryl substituted tetrahydropyrroloijquinolinone derivatives, which act as aldosterone synthase inhibitors, and for the synthesis of aminoarylpyridazines, which are selective CB2 agonists for the treatment of inflammatory pain.
Used in Chemical Research:
4-Isoquinolineboronic acid is used as a reactant for the preparation of acyl substituted indoles via palladium-catalyzed domino coupling/carbonylation/Suzuki coupling of dibromoethenylanilines, and for the synthesis of antagonists of bacterial quorum sensing.
Used in Cross-Coupling Reactions:
4-Isoquinolineboronic acid is used in the preparation of potassium heteroaryl trifluoroborates from boronic acids, which serve as coupling partners with various aryl and heteroaryl halides in Suzuki-Miyaura cross-coupling reactions, a widely used method in organic synthesis for the formation of carbon-carbon bonds.
Check Digit Verification of cas no
The CAS Registry Mumber 192182-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,1,8 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 192182-56:
(8*1)+(7*9)+(6*2)+(5*1)+(4*8)+(3*2)+(2*5)+(1*6)=142
142 % 10 = 2
So 192182-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BNO2/c12-10(13)9-6-11-5-7-3-1-2-4-8(7)9/h1-6,12-13H
192182-56-2Relevant articles and documents
A remarkable divergent fluorescence response to epimeric monosaccharides by an isoquinoline-derived diboronate
Garget, Taylor A.,Houston, Todd A.,Kiefel, Milton J.
supporting information, (2022/03/09)
Herein we report a new boronic acid fluorescent sensor based on 4-isoquinolineboronic acid that has a fluorescent divergent response biologically relevant monosaccharides, glucose and galactose. By analyzing the interactions of this sensor with several alternate sugar forms we have been able to determine how the boronic acid selects diols for binding and how such a molecule could have a positive and negative fluorescent response to two very similar hexoses.
Azabicyclic inhibitors of serotonin reuptake
-
, (2008/06/13)
This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes of furmula (I) which are useful for the inhibition of serotonin reuptake in mammals. whereA-B is -C=CH- or -CH-CH2/s
