192220-12-5

Basic information

• Product Name: Benzenemethanamine, N-[2-(phenylmethoxy)ethylidene]-, N-oxide
• CAS NO: 192220-12-5
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 192220-12-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-[2-(phenylmethoxy)ethylidene]-, N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-[2-(phenylmethoxy)ethylidene]-, N-oxide(192220-12-5)
• EPA Substance Registry System: Benzenemethanamine, N-[2-(phenylmethoxy)ethylidene]-, N-oxide(192220-12-5)

Safety Data

• Hazardous Substances Data: 192220-12-5(Hazardous Substances Data)

Upstream product

• 1400991-35-6 C₂₅H₃₀N₂O₂ 
• 1400991-34-5 C₂₃H₂₆N₂O₃ 
• 60656-87-3 benzyloxyacetoaldehyde 
• 622-30-0 N-benzyl hydroxylalmine 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 

Downstream Products

• 1400991-35-6 C₂₅H₃₀N₂O₂ 
• 952235-30-2 1-[N-benzyl-N-(hydroxy)amino]-2-[N'-(tert-butoxycarbonyl)amino]-1-(6'-methoxyindol-3'-yl)ethane 
• 858971-12-7 3-(2-benzyl-3-benzyloxymethyl-isoxazolidine-5-carbonyl)-oxazolidin-2-one 
• 858971-14-9 C₂₂H₂₄N₂O₅ 
• 1027988-27-7 C₂₂H₃₁NO₂Si 

Relevant articles and documents

Nucleophilic addition of nitrones to ketones: Development of a new catalytic asymmetric nitrone-aldol reaction

A new organic reaction has been discovered in which nitrones react with carbonyl compounds in an aldol-type reaction to give functionalized β-hydroxynitrones. The α-carbon atom of the nitrone undergoes a nucleophilic addition reaction to electron-deficient ketones, such as α-ketoesters, α, β-diketones, and trifluoromethyl ketones, to afford the products in moderate to good yields. The scope and potential of the reaction have been investigated and developed. The reaction can also be catalyzed by secondary amines. The use of chiral cyclic amines, such as L-proline leads to optically active β-hydroxynitrones in moderate yield and with moderate to high enantiomeric excess. The reaction mechanism was studied by kinetic measurements, intermediate and product analysis, and determination of the absolute configuration of the product; based on these investigations a mechanism for the new reaction is proposed.

NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS

Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

Synthesis and Iodocyclization of Homoallylic Hydroxylamines

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