192374-14-4 Usage
Description
(2S,3S)-2-(3-CHLORO-PHENYL)-3,5,5-TRIMETHYL-MORPHOLIN-2-OL HYDROCHLORIDE is a chiral compound with a specific enantiomeric configuration (S,S). It is characterized by the presence of a 3-chloro-phenyl group attached to a morpholinol structure, which is further substituted with trimethyl groups. (2S,3S)-2-(3-CHLORO-PHENYL)-3,5,5-TRIMETHYL-MORPHOLIN-2-OL HYDROCHLORIDE is a light beige solid, indicating its stability and potential for use in various applications.
Uses
Used in Pharmaceutical Industry:
(2S,3S)-2-(3-CHLORO-PHENYL)-3,5,5-TRIMETHYL-MORPHOLIN-2-OL HYDROCHLORIDE is used as an enantiomer metabolite for the development of chiral drugs. Its specific configuration (S,S) is crucial for the activity, safety, and efficacy of the resulting pharmaceutical products. The compound serves as a key intermediate in the synthesis of enantiomerically pure drugs, particularly in the field of antidepressants, such as Bupropion (B689625).
Used in Chemical Research:
As a chiral compound with a unique structure, (2S,3S)-2-(3-CHLORO-PHENYL)-3,5,5-TRIMETHYL-MORPHOLIN-2-OL HYDROCHLORIDE can be used in chemical research for the development of novel chiral catalysts, ligands, and other chiral auxiliaries. Its specific stereochemistry and functional groups make it a valuable building block for the synthesis of complex organic molecules with potential applications in various industries.
Used in Analytical Chemistry:
The compound's distinct enantiomeric configuration and chemical properties make it suitable for use in analytical chemistry, particularly in the development of chiral stationary phases for high-performance liquid chromatography (HPLC) and other separation techniques. These techniques are essential for the analysis and purification of enantiomers in pharmaceuticals, agrochemicals, and other chiral compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 192374-14-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,3,7 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 192374-14:
(8*1)+(7*9)+(6*2)+(5*3)+(4*7)+(3*4)+(2*1)+(1*4)=144
144 % 10 = 4
So 192374-14-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H18ClNO2/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3
192374-14-4Relevant articles and documents
HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE
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Page/Page column 54, (2011/12/04)
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
ENZYME-CATALYZED DYNAMIC KINETIC RESOLUTION PROCESS FOR PREPARING (+)-(2S, 3S)-2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYL-2-MORPHOLINOL, SALTS, AND SOLVATES THEREOF
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Page/Page column 23-24, (2008/06/13)
A process for preparing (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, pharmaceutically acceptable salts and solvates thereof such as the (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride salt via enzyme-cataly
