1923833-60-6

Basic information

• Product Name: BMS-986205
• Synonyms: BMS-986205;Linrodostat
• CAS NO: 1923833-60-6
• Molecular Formula: C24H24ClFN2O
• Molecular Weight: 410.9115632
• Product Categories: API
• Mol File: 1923833-60-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 606.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 13.80±0.70(Predicted)
• CAS DataBase Reference: BMS-986205(CAS DataBase Reference)
• NIST Chemistry Reference: BMS-986205(1923833-60-6)
• EPA Substance Registry System: BMS-986205(1923833-60-6)

Safety Data

• Hazardous Substances Data: 1923833-60-6(Hazardous Substances Data)

Usage

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Uses

BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.

Upstream product

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Relevant articles and documents

Rapid Development of a Commercial Process for Linrodostat, an Indoleamine 2,3-Dioxygenase (IDO) Inhibitor

The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. The synthesis features several highly efficient telescoped processes and the use of Evans auxiliary to install a methyl-bearing stereocenter. The target was prepared in 12 steps with 7 isolations in an overall yield of 31%.

IMMUNOREGULATORY AGENTS

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.