19246-13-0Relevant articles and documents
CHENODEOXYCHOLIC ACID SYNTHESIS IN THE HAMSTER: A METABOLIC PATHWAY VIA 3β,7α-DIHYDROXY-5-CHOLEN-24-OIC ACID
Kulkarni, Bharti,Javitt, Norman B.
, p. 581 - 590 (1982)
The quantitative significance of the metabolism of 3β,7α-dihydroxy-5-cholen-24-oic acid to chenodeoxycholic acid was evaluated in the hamster.A precursor-product relationship was established in this species by the finding that intravenous administration to an animal previously given cholesterol-4-14C caused a significant reduction in the specific activity of chenodeoxycholic acid.Administration of 12.9 μmole of the precursor was followed by a 10-fold increase in chenodeoxycholic acid excretion although the predominant excretory pathway was via biliary excretion as a monosulfate.The data indicate that synthesis of bile acid from cholesterol via the intermediate 3β,7α-dihydroxy-5-cholen-24-oic acid can be a quantitatively important pathway.
A convenient synthesis of 3β,12α-, 3β,7α-, and 3β,7β-dihydroxy-5-cholen-24-oic acids: Unusual bile acids in human biological fluids
Tohma,Mahara,Takeshita,Kurosawa
, p. 331 - 338 (2007/10/02)
The unusual bile acids 3β,12α- (V), 3β,7α- (XIIIa), and 3β,7β- (XIIIb) dihydroxy-5-cholen-24-oic acids were synthesized conveniently from the 3-oxo derivatives of deoxycholic (I) and lithocholic (VI) acids, respectively, to provide authentic samples for the gas chromatography-mass spectrometric determination of these bile acids in the abnormal metabolism of bile acids.
