19249-03-7Relevant articles and documents
Synthesis and characterisation of schiff base macrocyclic Pb(II), zn(ii), Cd(II) and La(III) complexes by template reaction of (±)-trans-1,2- diaminocyclohexane with metal nitrates and salicylaldehyde derivatives
Ilhan, Salih
, p. 766 - 769 (2009)
Eight macrocyclic complexes have been synthesised by template reaction of (±)-trans-1,2-diaminocyclohexane with metal nitrates and 1,10-bis(2-formylphenyl)-1,4,7,10-tetraoxadecane or 1,7-bis(2-formylphenyl)-1,4, 7-trioxaheptane, and their structures are proposed on the basis of elemental analysis, FT-IR, UV-Vis, molar conductivity measurements, 1H The complexes NMR and mass spectra. The metal-to-ligand molar ratios are 1:1 in the complexes, which are 1:2 electrolytes for Pb(II), Cd(II) and Zn(II) and 1:3 electrolytes for La(III).
A multi-responsive crown ether-based colorimetric/fluorescent chemosensor for highly selective detection of Al3+, Cu2+ and Mg2+
Zhang, Qiang,Ma, Ruifang,Li, Zhuying,Liu, Zizhong
, (2020)
A novel multi-response chemosensor L based on coumarin-chalcone-crown ether was designed and synthesized, which exhibited a high selectivity for the colorimetric detecting Al3+ and Cu2+ and fluorescent recognizing Al3+ and Mg2+ in ethanol. L can monitor Al3+ and Cu2+ via distinct color changes from a slight yellow to pink and to orange, respectively. The sensor L can also monitor Al3+ and Mg2+ by fluorescence emission responses at 592 nm and 547 nm with low detection limits of 0.31 μM and 0.23 μM, respectively. The selectivity of L toward Al3+, Cu2+ and Mg2+ was not interfered by a large number of coexisting ions and was found to be reversible. By means of spectrometric titration, Job's plot, mass spectrometry, 1H NMR titration and IR spectroscopy analysis, it was unanimously confirmed that the sensor L had a stoichiometric ratio of 1:1 with Cu2+ and Mg2+, and 1:2 with Al3+. The order of the stability of the complexes formed by L and Al3+, Cu2+, Mg2+ was as follows: L-Al3+ > L-Cu2+ > L-Mg2+. At the same time, some possible bonding modes and sensing mechanisms were further proposed, and the optimized structure of the sensor L and its sensing mechanism for Al3+, Cu2+ and Mg2+ were confirmed by the calculations of DFT/B3LYP and TD-DFT methods in a suite of Gaussian 09 programs.
Metal ion chemosensors based on diaza-18-crown-6 coupling with azobenzene dye
Koonrugsa, Narongsak,Fuangswasdi, Saowarux
, p. 15 - 23 (2019)
Novel naked-eye cation-selective chemosensors were developed from derivatives of diaza-18-crown-6 bearing one or two azobenzenes functionalized with o-acetic acid or p-nitro groups. The chromogenic acid and nitro derivatives exhibited solvatochromic effects with a majority of quinone-hydrazone tautomer in DMSO. The study of sensing properties of all molecules towards several metal ions showed that the one and two nitro-bearing N1 and N2 derivatives responded selectively to Cr3+ in MeCN with a color change from pink to colorless. They also showed selectivity for Hg2+ in DMSO with a color change from purple to light yellow. The detection limit of N1 and N2 that render visual difference to the naked eye are 0.21 ppm and 0.31 ppm for Cr3+ in MeCN, and 1.20 ppm and 1.00 ppm for Hg2+ in DMSO, while that obtained from 3σ method are 0.08 ppm and 0.03 ppm for Hg2+ in DMSO. These results demonstrate a potential use of p-nitro azobenzene diaza-18-crown-6 as naked-eye sensors, notably for Cr3+ that brings acute toxic to aquatic life.
Sodium-Selective Fluoroionophore-Based Optodes for Seawater Salinity Measurement
Müller, Bernhard J.,Rappitsch, Tanja,Staudinger, Christoph,Rüschitz, Christian,Borisov, Sergey M.,Klimant, Ingo
, p. 7195 - 7202 (2017)
A new fluorescent sensor for Na+ is presented. The sensor relies on a Na+ selective fluoroionophore based on a bright red-emitting BODIPY chromophore. The fluorescence of the fluoroionophore is enhanced upon binding of Na+-ions to the highly selective aza-crown ether receptor due to reduction of the photoinduced electron transfer (PET) quenching. Solid state sensing materials were prepared by physically embedding the fluoroionophore into water-swellable biocompatible polymer matrices (polyurethane hydrogels), thus enabling continuous measurements of aqueous samples. Despite the simple design, the sensor showed no leaching of the indicator and featured fast and reversible response. Among different polyurethane hydrogels investigated, the hydrogel D1 featuring the highest water uptake was found to be the most suitable due to the highest dynamics between "off" and "on" states. Due to little or no cross sensitivity to other ions (e.g., Mg2+, Ca2+, K+) and its insensitivity to potential changes in pH, this sensor is promising for use in clinical diagnostics and for biological and marine applications. Fiber-optic sensors based on referenced read-out with a compact phase fluorimeter were prepared. To demonstrate their practical applicability, the sensors were used to determine the salinity in the seawater and brackish water of the Baltic Sea.
Displacement assay detection by a dimeric lanthanide luminescent ternary Tb(iii)-cyclen complex: High selectivity for phosphate and nitrate anions
Caffrey, David F.,Gunnlaugsson, Thorfinnur
, p. 17964 - 17970 (2014)
The luminescent dimeric ternary lanthanide-cyclen complexes (2-(Ln.1)2; Ln = Tb/Eu) were designed and both their self-assembly formation and their ability to detect anions via displacement assays were investigated using spectrophotometric titrations in MeOH solution. The formation of 2-(Tb.1)2 and 2-(Eu.1)2 was investigated in solution, and determination of the binding constants and stoichiometry showed that the former was formed almost exclusively over the 1 1 complex 2-(Tb.1) after the addition of two equivalents of 2; while for 2-(Eu.1)2 a mixture of both stoichiometries existed even after the addition of four equivalents of 2. Of these two systems, 2-(Tb.1)2 was studied in details as a probe for anions, where significant changes where observed in the photophysical properties of the complex; with the characteristic Tb(iii)-centred emission being fully switched off upon the sensing of phosphates and nitrate, giving rise to the formation of a H2PO4-:Tb.1 complex in a 1 2 stoichiometry upon sensing of H2PO4- by 2-(Tb.1)2, while NO3- gave 1 1 complex formation and two equivalents of NO3-·Tb.1.
MODULAR CHEMICAL PROBE FOR DETECTION OF AMINO ACID CITRULLINE IN PHYSIOLOGICAL SAMPLES
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Page/Page column 16, (2021/01/29)
An improved chemical probe for the detection of the amino acid citrulline combines: 1) a reactive head formed of 1,3-dicarbonyl moiety that reacts with a citrulline side chain in an improved manner compared to currently used 1,2-dicarbonyl moieties; and 2) a modular action of the probe where citrulline side chains are labeled first using reactive heads described above, and attachment of a read-out subunit or tag, be it a fluorophore, a nanoparticle, or an antigen is performed separately. The modular nature of the chemical probe increases the sensitivity of the probes due to their smaller size. Additionally, the chemical probes of the present disclosure allow the same sample to be analyzed using a variety of read-out methods.
DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
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Paragraph 0094-0095, (2021/03/19)
To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where each X may be the same or different to represent H, Cl, OMe, or, Me, Y is H, a phenyl group, a substituted carbamoyl group or the like).SELECTED DRAWING: None
DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX
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Paragraph 0073-0074, (2021/03/19)
To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.SOLUTION: The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal complex thereof (where X is H or a substituted carbamoyl group, R1, R2, R3, and R4 independently represent H or a C1-8 linear or branched alkyl group).SELECTED DRAWING: None