19255-80-2

Basic information

• Product Name: 1H-Pyrazole-3,5-dicarboxylic acid, 4,5-dihydro-, dimethyl ester
• CAS NO: 19255-80-2
• Molecular Formula: C7H10N2O4
• Molecular Weight: 186.167
• Mol File: 19255-80-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3,5-dicarboxylic acid, 4,5-dihydro-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3,5-dicarboxylic acid, 4,5-dihydro-, dimethyl ester(19255-80-2)
• EPA Substance Registry System: 1H-Pyrazole-3,5-dicarboxylic acid, 4,5-dihydro-, dimethyl ester(19255-80-2)

Safety Data

• Hazardous Substances Data: 19255-80-2(Hazardous Substances Data)

Upstream product

• 38256-25-6 dimethyl (E)-2-oxoglutaconate 
• 6832-16-2 methyl diazoacetate 
• 292638-85-8 acrylic acid methyl ester 
• 54761-04-5 ytterbium(III) triflate 

Downstream Products

• 4077-76-3 3,5-dicarbomethoxypyrazole 
• 1421-04-1 2,4-diaminopentanedioic acid 
• 1724-02-3 glutaconic acid 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 
• 696-74-2 cis-1,2-cyclopropanedicarboxylic acid 
• 15719-64-9 methylammonium carbonate 
• 302-01-2 hydrazine 
• 189450-22-4 cis-3-amino-5-methoxycarbonylpyrrolidin-2-one 
• 189450-22-4 trans-3-amino-5-methoxycarbonylpyrrolidin-2-one 

Relevant articles and documents

Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures

A novel conformationally constrained pyridazinone Eag-base PNA-monomer 2 capable of binding thymine in a triplex motif was designed and synthesised. A bis-PNA with the Eag-base incorporated in the Hoogsteen strand was hybridised with a complementary DNA. Thermal stability studies revealed an increase in Tm (4.3°C per mod.) compared to a no-base unit, but showed no improvement over a previously described unconstrained analogue (E, 1). Surprisingly, no significant difference was found in the thermodynamic parameters (ΔH°, ΔS° and ΔG°) for PNA-DNA triplex formation involving 2 or the unconstrained analogue 1.