192815-71-7

Basic information

• Product Name: 5-phenylmorpholin-3-one
• Synonyms: 5-phenylmorpholin-3-one;(5R)-5-Phenyl-3-morpholinone;(R)-5-Phenylmorpholin-3-one;(5R)-5-Phenylmorpholin-3-one
• CAS NO: 192815-71-7
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177
• Mol File: 192815-71-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.149
• CAS DataBase Reference: 5-phenylmorpholin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenylmorpholin-3-one(192815-71-7)
• EPA Substance Registry System: 5-phenylmorpholin-3-one(192815-71-7)

Safety Data

• Hazardous Substances Data: 192815-71-7(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 105-39-5 chloroacetic acid ethyl ester 
• 94193-77-8 (R)-N-(2-hydroxy-1-phenylethyl)-2-chloroacetamide 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 957121-46-9 tert-butyl (5R)-3-oxo-5-phenylmorpholine-4-carboxylate 
• 1429228-65-8 (R)-tert-butyl 3-(4-iodophenyl)morpholine-4-carboxylate 
• 1429228-66-9 tert-butyl (3R)-3-(4-methoxycarbonylphenyl)morpholine-4-carboxylate 
• 1429228-67-0 tert-butyl (3R)-3-[4-(hydroxymethyl)phenyl]morpholine-4-carboxylate 
• 1429228-68-1 tert-butyl (3R)-3-(4-formylphenyl)morpholine-4-carboxylate 
• 1429228-69-2 tert-butyl (3R)-3-{4-[(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate 
• 1429228-71-6 tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate 
• 1429228-63-6 5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine 
• 1429228-72-7 tert-butyl (3R)-3-[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromo-pyrazin-2-yl]isoxazol-3-yl]phenyl]morpholine-4-carboxylate 
• 1429228-64-7 (R)-tert-butyl 3-phenylmorpholine-4-carboxylate 
• 138713-44-7 3-(-)-Phenyl morpholine 
• 107-92-6 butyric acid 

Relevant articles and documents

SUBSTITUTED MORPHOLINE DERIVATIVES AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, X1, X2, m and n are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORyt). These compounds prevent, inhibit, or suppress the action of RORyt and are therefore useful in the treatment of RORyt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. (I)

COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

The invention relates to the compound 5-(4-isopropylsulfonylphenyl) -3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazine-2-amine and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of ATR kinase.

Cycloadditions of chiral carbonyl ylides with imine dipolarophiles as a route to enantiomerically pure α-amino-β-hydroxy acids

The preparation of enantiomerically pure threo-β-amino-α-hydroxy acids via 1,3-dipolar cycloadditions of imine dipolarophiles with the chiral isomuenchnone derived from (5R)-5-phenylmorpholin-3-one 1 is described. The cycloadducts were obtained with excellent diastereofacial- and exo-selectivity. Subsequent hydrolysis and chemoselective exocyclic amide cleavage afforded the threo-β-amino-α-hydroxy acids with recovery of the initial chiral auxiliary.