192862-15-0

Basic information

• Product Name: 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone
• Synonyms: 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone
• CAS NO: 192862-15-0
• Molecular Weight: 270.223
• Mol File: 192862-15-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone(192862-15-0)
• EPA Substance Registry System: 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone(192862-15-0)

Safety Data

• Hazardous Substances Data: 192862-15-0(Hazardous Substances Data)

Upstream product

• 95727-89-2 4-(trifluoromethyl)phenyl chloromethylketone 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 136067-94-2 2‐(methylsulfanyl)‐1‐[4‐(trifluoromethyl)phenyl]ethanone 

Downstream Products

• 192861-89-5 1,1-difluoro-1-(methylthio)-3-(1H-1,2,4-triazol-1-yl)-2-[4-(trifluoromethyl)phenyl]-2-propanol 
• 192862-20-7 2-[difluoro(methylthio)methyl]-2-[4-(trifluoromethyl)phenyl]oxirane 

Relevant articles and documents

Preparation process of difluoroacetophenone derivative

The invention relates to a process for preparing a difluoroacetophenone derivative (4) by alkylthionating a compound (1) into a compound (2) and reacting this compound with a compound (3). wherein X1is Cl, Br or I, X2and X3/sup

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).