192865-77-3

Basic information

• Product Name: [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester
• Synonyms: [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester;4'-(Dimethylamino)-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
• CAS NO: 192865-77-3
• Molecular Formula: C17H19NO2
• Molecular Weight: 269
• Mol File: 192865-77-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester(192865-77-3)
• EPA Substance Registry System: [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester(192865-77-3)

Safety Data

• Hazardous Substances Data: 192865-77-3(Hazardous Substances Data)

Usage

Description

[1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester, also known as ethyl 4-(dimethylamino)benzoyloxybenzoate, is a chemical compound with a biphenyl core and an ester functional group. It is commonly utilized in organic synthesis and pharmaceutical research due to its versatile structure and potential biological activity.

Uses

Used in Organic Synthesis:
[1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester is used as a building block in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable component in creating a wide range of molecules for different applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester is used as a potential candidate for drug discovery and development. Its dimethylamino group and ester functional group contribute to its potential pharmacological properties, making it a promising compound for further research and development into new medications.
Used in Chemical Research:
[1,1'-Biphenyl]-4-carboxylic acid, 4'-(dimethylamino)-, ethyl ester is also utilized in chemical research to study its properties and interactions with other molecules. Understanding its reactivity and behavior can lead to the development of new synthetic methods and applications in various scientific fields.

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 131379-16-3 4-(ethoxycarbonyl)phenylzinc iodide 
• 28276-32-6 ethyl p-mercaptobenzoate 
• 93296-10-7 (4-(dimethylamino)phenyl)zinc(II) chloride 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 121-69-7 N,N-dimethyl-aniline 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 
• 1394949-85-9 C₁₂H₁₈NO₂⁽¹⁺⁾*Br^(1-) 
• 10287-53-3 ethyl p-dimethyaminolbenzoate 

Relevant articles and documents

Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents

Cross-coupling of (hetero)arylthiols with arylzinc reagents via C-S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg2+ and Li+ ions were demonstrated to facilitate the reaction.

New hydrogen halide salt

PROBLEM TO BE SOLVED: To provide novel substances excellent in water solubility and available as luminescent substrates in firefly bioluminescent systems.SOLUTION: There are provided hydrogen halide salts of compounds represented by the specified general formula (I) or the specified general formula (II).

Nickel complexes supported by quinoline-based ligands: Synthesis, characterization and catalysis in the cross-coupling of arylzinc reagents and aryl chlorides or aryltrimethylammonium salts

Lithium and nickel complexes bearing quinoline-based ligands have been synthesized and characterized. Reaction of 8-azidoquinoline with Ph 2PNHR (R = p-MeC6H4, But) affords N-(8-quinolyl)iminophosphoranes RNHP(Ph2)N(8-C9H 6N) (1a, R = p-MeC6H4; 1b, R = But. C9H6N = quinolyl)). Reaction of 1a with (DME)NiCl 2 generates a nickel complex [NiCl2{N(8-C 9H6N)P(Ph2)NH(p-MeC6H4)}] (2a). Treatment of 1b with (DME)NiCl2 and following with NaH produces [NiCl{(1,2-C6H4)P(Ph)(NHBut)N(8-C 9H6N)}] (4). Complex 4 was also obtained by reaction of (DME)NiCl2 with [Li{(1,2-C6H4)P(Ph)(NHBu t)N(8-C9H6N)}] (5) prepared through lithiation of 1b. Reaction of 2-PyCH2P(Ph2)N(8-C9H 6N) (6, Py = pyridyl) and PhNC(Ph)CH2P(Ph 2)N(8-C9H6N) (8), respectively, with (DME)NiCl2 yields two five-coordinate N,N,N-chelate nickel complexes, [NiCl2{2-PyCH2P(Ph2)N(8-C9H 6N)}] (7) and [NiCl2{PhNC(Ph)CH2P(Ph 2)N(8-C9H6N)}] (9). Similar reaction between Ph2PCH2P(Ph2)N(8-C9H6N) (10) and (DME)NiCl2 results in five-coordinate N,N,P-chelate nickel complex [NiCl2{Ph2PCH2P(Ph2)N(8- C9H6N)}] (11). Treatment of [(8-C9H 6N)NP(Ph2)]2CH2 (12) [prepared from (Ph2P)2CH2 and 2 equiv. of 8-azidoquinoline] with LiBun and (DME)NiCl2 successively affords [NiCl{(8-C9H6N)NP(Ph2)}2CH] (13). The new compounds were characterized by 1H, 13C and 31P NMR spectroscopy (for the diamagnetic compounds), IR spectroscopy (for the nickel complexes) and elemental analysis. Complexes 2a, 4, 7, 9, 11 and 13 were also characterized by single-crystal X-ray diffraction techniques. The nickel complexes were evaluated for the catalysis in the cross-coupling reactions of arylzinc reagents with aryl chlorides and aryltrimethylammonium salts. Complex 7 exhibits the highest activity among the complexes in catalyzing the reactions of arylzinc reagents with either aryl chlorides or aryltrimethylammonium bromides.