193071-75-9

Basic information

• Product Name: 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-, (1R,3S,7S,10R,11S,12S,16S)-
• CAS NO: 193071-75-9
• Molecular Formula: C26H39NO6S
• Molecular Weight: 493.665
• Mol File: 193071-75-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-, (1R,3S,7S,10R,11S,12S,16S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-, (1R,3S,7S,10R,11S,12S,16S)-(193071-75-9)
• EPA Substance Registry System: 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thi azolyl)ethenyl]-, (1R,3S,7S,10R,11S,12S,16S)-(193071-75-9)

Safety Data

• Hazardous Substances Data: 193071-75-9(Hazardous Substances Data)

Upstream product

• 186692-73-9 desoxyepothilone A 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Relevant articles and documents

Epothilones C, E and F

Epothilone derivatives are obtained by: (1) cultivation of Sorangium cellulosum DSM 6773 in the presence of an absorption resin; (2) separation of the resin and culture followed by washing with aqueous methanol; (3) eluting the washed resin with methanol and reducing the extract; (4) partitioning the extract between methanol and hexane; (5) reducing the methanolic phase and fractionating it on a Sephadex column, and (6) isolation of the epothilones by chromatography using a methanol/water mixture. Epothilone A is followed by epothilone B, and two further fractions.

Epothilone derivatives, their preparation and utilization

Epothilone derivatives of formula (I)-(III) are new. R = H or 1-4C alkyl; Y Z = H, halo, pseudohalogen, OH, 1-6C acyloxy, 1-6C alkoxy or benzoyloxy; or Y+Z = bond or O; (a) R' = Q; A = H; B = OR1; and R" = R2; or R"+B = C(O)O, C(S)O, S(O)O, Si(R")2O or C(

The olefin metathesis approach to epothilone A and its analogues

The olefin metathesis approach to epothilone A (1) and several analogues (39-41, 42-44, 51-57, 58-60, 64-65, and 67-69) is described. Key building blocks 6-8 were constructed in optically active form and were coupled and elaborated to olefin metathesis pr