19336-96-0Relevant articles and documents
Organotin(IV) derivatives based on 2-((2-methoxyphenyl)carbamoyl)benzoic acid: Synthesis, spectroscopic characterization, assessment of antibacterial, DNA interaction, anticancer and antileishmanial potentials
Sirajuddin, Muhammad,Ali, Saqib,Tahir, Muhammad Nawaz
, (2021)
A series of ten organotin(IV) carboxylate derivatives of 2-((2-methoxyphenyl)carbamoyl)benzoic acid were prepared and confirmed by FTIR, CHN analysis and single crystal XRD (SCXRD) as well as by NMR and mass spectrometry. The microelemental CHN analysis results give a close matching with those of the theoretical values of CHN atoms. The results of the solid state SCXRD for the complex 3 reveals a trigonal bipyramidal geometry (TBG) with slight distortion for the R3SnL derivatives. Further confirmation about the 5-coordinated TBG may also be achieved from the τ value which is 0.87 for the complex 3. It is obvious from the crystal structure of the complex 3 that the involvement of the O1 of the carboxylate moiety and O3 of the amide moiety with Sn atom are responsible for formation of the polymeric structure having 5-coordinated TBG. The comparison of SCXRD value (124.8°) and that of 13C NMR value (123°) for C-Sn-C angle in complex 3 is the best confirmation of 5-coordinated TBG for the R3SnL derivatives. The evaluated compounds interact with DNA by an intercalative type of binding as displayed by the results obtained from UV-vis. and viscosity measurements. The results of the antimicrobial activity of the evaluated compounds in comparison to the standard drugs demonstrate that the tested compounds possess good antimicrobial potentials. The cytotoxicity results obtained against H-157 and BHK-21 cell lines using Sulforhodamine B based method show that compound 1 has the maximum activity among the studied compounds and its activity is comparable to that of the vincristine. The small IC50 value for the compound 1 as compared to the standard antileishmanial drug, Amphotericin B, proves the efficiency of the tested compounds for the treatment of leishmania disease.
COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS
-
Paragraph 0739; 0876, (2014/09/29)
Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.
Kinetics and mechanism of large rate enhancement in the alkaline hydrolysis of N′-morpholino-N-(2′-methoxyphenyl)phthalamide
Sim, Yoke-Leng,Ariffin, Azhar,Khan, M. Niyaz
, p. 3730 - 3737 (2008/09/20)
(Chemical Equation Presented) The apparent second-order rate constant (kOH) for hydroxide-ion-catalyzed conversion of 1 to N-(2′-methoxyphenyl)phthalamate (4) is ～103-fold larger than kOH for alkaline hydrolysis of N-morpholinobenzamide (2). These results are explained in terms of the reaction scheme 1→ k1obs3→k2obs4 where 3 represents N-(2′- methoxyphenyl)phthalimide and the values of k2obs/k1obs vary from 6.0 × 102 to 17 × 102 within [NaOH] range of 5.0 × 10-3 to 2.0 M. Pseudo-first-order rate constants (kobs) for alkaline hydrolysis of 1 decrease from 21.7 × 10-3 to 15.6 × 10-3 s-1 with an increase in ionic strength (by NaCl) from 0.5 to 2.5 M at 0.5 M NaOH and 35°C. The values of kobs, obtained for alkaline hydrolysis of 2 within [NaOH] range 1.0 × 10-2 to 2.0 M at 35°C, follow the relationship kobs = kOH[HO-] + kOH′[HO -]2 with least-squares calculated values of kOH and kOH′ as (6.38 ± 0.15) × 10-5 and (4.59 ± 0.09) × 10-5 M-2 s-1, respectively. A few kinetic runs for aqueous cleavage of 1, N′-morpholino- N-(2′-methoxyphenyl)-5-nitrophthalamide (5) and N′-morpholino-N- (2′-methoxyphenyl)-4-nitrophthalamide (6) at 35°C and 0.05 M NaOH as well as 0.05 M NaOD reveal the solvent deuterium kinetic isotope effect (= kobsH2O/kobsD2O) as 1.6 for 1, 1.9 for 5, and 1.8 for 6. Product characterization study on the cleavage of 5, 6, and N-(2′-methoxyphenyl)-4-nitrophthalimide (7) at 0.5 M NaOD in D 2O solvent shows the imide-intermediate mechanism as the exclusive mechanism.
