19339-62-9

Basic information

• Product Name: 2-NAPHTHOYLMETHYL THIOCYANATE
• Synonyms: thiocyanicacid,2-naphthoylmethylester;2-(2-NAPHTHYL)-2-OXOETHYL THIOCYANATE;2-NAPHTHOYLMETHYL THIOCYANATE;2-Naphth-2-yl-2-oxoethyl thiocyanate;2-NAPHTHOYLMETHYL THIOCYANATE, 95+%;Thiocyanic acid 2-(2-naphthalenyl)-2-oxoethyl ester;(2-naphthalen-2-yl-2-oxoethyl) thiocyanate;(2-naphthalen-2-yl-2-oxo-ethyl) thiocyanate
• CAS NO: 19339-62-9
• Molecular Formula: C₁₃H₉NOS
• Molecular Weight: 227.28
• EINECS: 604-604-1
• Mol File: 19339-62-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 107-109
• Boiling Point: 434.3 °C at 760 mmHg
• Flash Point: 216.4 °C
• Appearance: /
• Density: 1.27 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-NAPHTHOYLMETHYL THIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NAPHTHOYLMETHYL THIOCYANATE(19339-62-9)
• EPA Substance Registry System: 2-NAPHTHOYLMETHYL THIOCYANATE(19339-62-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 19339-62-9(Hazardous Substances Data)

Usage

General Description

2-Naphthoylmethyl thiocyanate is a chemical compound with the molecular formula C17H11NOS. It is a thiocyanate derivative of 2-naphthylmethyl, and is a white to light brown solid that is soluble in organic solvents. 2-NAPHTHOYLMETHYL THIOCYANATE is commonly used as a reagent in organic synthesis, particularly in the preparation of thiosemicarbazones. It is also used as a starting material for the synthesis of other organic compounds with potential pharmaceutical or agricultural applications. 2-Naphthoylmethyl thiocyanate has been studied for its potential biological activity, but its physiological effects and potential hazards are not well documented.

InChI:InChI=1/C13H9NOS/c14-9-16-8-13(15)12-6-5-10-3-1-2-4-11(10)7-12/h1-7H,8H2

Upstream product

• 540-72-7 sodium thiocyanide 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 93-08-3 methyl 2-naphthyl ketone 
• 827-54-3 2-naphthylethylene 
• 613-54-7 2-Bromo-2'-acetonaphthone 

Downstream Products

• 412923-59-2 2-bromo-4-(naphthalen-2-yl)thiazole 

Relevant articles and documents

Iodine/MeOH as a novel and versatile reagent system for the synthesis of α-ketothiocyanates

Ketones possessing α-hydrogens undergo smooth thiocyanation with ammonium thiocyanate in the presence of molecular iodine in refluxing methanol to produce the corresponding α-ketothiocyanates in excellent yields with high selectivity. The use of iodine ma

Visible-light-promoted thiocyanation of sp2C-H bonds over heterogeneous graphitic carbon nitrides

Mesoporous graphitic carbon nitride (mpg-C3N4) has been developed as a metal-free heterogeneous photocatalyst for thiocyanation transformations. The reaction proceeds efficiently by utilizing air as a green oxidant under mild reaction conditions, which affords SCN-containing compounds in moderate to excellent yields. Meanwhile, the practicality of this protocol is further demonstrated by the reusability of the mpg-C3N4photocatalyst and the scaled-up reaction. Furthermore, detailed mechanistic studies clearly demonstrate the role of oxygen.

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment

SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types inclu

Synthesis of ionic liquid-supported hypervalent iodine reagent and its application as a 'catch and release' reagent for α-substituted acetophenones

A novel imidazolium-based ionic liquid-supported hypervalent iodine reagent has been synthesized and employed for a 'catch and release' strategy with substituted acetophenones to generate various α-substituted acetophenones in good to excellent yields. The use of an ionic liquid-supported hypervalent iodine reagent avoids chromatographic separation for the purification of α-substituted acetophenones and thus makes the method greener.