19343-85-2

Basic information

• Product Name: 2-Carboxyethylthiosuccinic acid (CETSA)
• Synonyms: 2-Carboxyethylthiosuccinic acid (CETSA);2-Carboxyethylthiosuccinic acid;CETSA;Butanedioic acid,2-[(2-carboxyethyl)thio]-
• CAS NO: 19343-85-2
• Molecular Formula: C₇H₁₀O₆S
• Molecular Weight: 222.2819
• EINECS: 1312995-182-4
• Mol File: 19343-85-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 151 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 432.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.561±0.06 g/cm3(Predicted)
• PKA: 3.47±0.23(Predicted)
• CAS DataBase Reference: 2-Carboxyethylthiosuccinic acid (CETSA)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Carboxyethylthiosuccinic acid (CETSA)(19343-85-2)
• EPA Substance Registry System: 2-Carboxyethylthiosuccinic acid (CETSA)(19343-85-2)

Safety Data

• Hazardous Substances Data: 19343-85-2(Hazardous Substances Data)

Usage

General Description

2-Carboxyethylthiosuccinic acid (CETSA) is a chemical compound that was primarily developed for the treatment of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). It is an investigational drug that is not yet approved for commercial use. As an experimental therapeutic, CETSA's main function is to inhibit the enzyme activity likely implicated in the progression of ALS. It is an organic compound, specifically a carboxylic acid, which is synthesized in the lab. Its chemical structure is characterized by several functional groups, such as carboxyl and thioester, which may be responsible for its bioactive properties in drug research.

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Relevant articles and documents

Evaluation of corrosion inhibition performance of a novel ionic liquid based on synergism between cation and anion

A novel ionic liquid, 1-butyl-1H-imidazol-1-ium 3-carboxy-2-((2-carboxylatoethyl)thio)propanoate ([Bhim]CETSA), was synthesized as an environmentally friendly and efficient corrosion inhibitor, and its corrosion inhibition performance on A3 steel in 1 M HCl solution was investigated by using the weight loss method, and the results indicated that the inhibition efficiency reached up to 90.11% when the concentration of [Bhim]CETSA was 10 mM at 298 K. There was a synergistic effect between anion and cation, and the anion played a major role in the corrosion inhibition of [Bhim]CETSA. The adsorption of ionic liquid on the A3 steel surface followed a Langmuir adsorption model and was proved by using infrared spectroscopy (IR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM), and the relevant thermodynamic parameters were calculated and discussed. Moreover, the existence of the hydrophobic film on the A3 steel was proven by contact angle measurement, and the corrosion inhibition mechanism of [Bhim]CETSA was further studied by quantum chemical calculation.