19354-50-8

Basic information

• Product Name: 3-methoxybenzo[b]thiophene-3-carboxylic acid
• Synonyms: 3-methoxybenzo[b]thiophene-3-carboxylic acid;3-Methoxybenzo[b]thiophene-2-carboxylic acid;Einecs 242-987-2
• CAS NO: 19354-50-8
• Molecular Formula: C₁₀H₈O₃S
• Molecular Weight: 208.23372
• EINECS: 242-987-2
• Mol File: 19354-50-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 395.9°Cat760mmHg
• Flash Point: 193.3°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 5.59E-07mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 3-methoxybenzo[b]thiophene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxybenzo[b]thiophene-3-carboxylic acid(19354-50-8)
• EPA Substance Registry System: 3-methoxybenzo[b]thiophene-3-carboxylic acid(19354-50-8)

Safety Data

• Hazardous Substances Data: 19354-50-8(Hazardous Substances Data)

Usage

General Description

3-Methoxybenzo[b]thiophene-3-carboxylic acid is a chemical compound with the molecular formula C11H8O3S. It is a derivative of benzo[b]thiophene, which is a heterocyclic aromatic compound containing a thiophene ring fused to a benzene ring. The presence of a carboxylic acid group in the molecule indicates its acidity and potential for involvement in chemical reactions. The methoxy group at the 3-position of the benzene ring contributes to the compound's overall structure and properties. This chemical may have applications in organic synthesis, pharmaceuticals, and materials science due to its unique structure and potential reactivity.

InChI:InChI=1/C10H8O3S/c1-13-8-6-4-2-3-5-7(6)14-9(8)10(11)12/h2-5H,1H3,(H,11,12)

Upstream product

• 147-93-3 Thiosalicylic acid 
• 5556-20-7 ethyl 3-hydroxybenzothiophene-2-carboxylate 
• 4892-02-8 Methyl thiosalicylate 
• 13134-76-4 methyl 3-hydroxybenzo[b]thiophene-2-carboxylate 
• 394-35-4 methyl 2-fluorobenzoate 
• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 19354-51-9 methyl 3-methoxybenzothiophene-2-carboxylate 
• 606-27-9 methyl 2-nitrobenzoate 
• 2365-48-2 Methyl thioglycolate 

Relevant articles and documents

Annulation of eight-to ten-membered oxaza rings to the benzo[b]thiophene system by intramolecular nucleophilic displacement

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)- one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramolecular nucleophilic displacement in the key ring forming step.

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the “Malaria Box”. After analysis of the data set, we have carried out a medicinal chemistry campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported.

ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS

This invention is directed to compounds of formula (III): STR1 wherein B, C, D, E, R 1, R 2 and R 3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.