19380-80-4

Basic information

• Product Name: 1-(2-chlorobenzyl)thiourea
• Synonyms: 1-(2-chlorobenzyl)thiourea
• CAS NO: 19380-80-4
• Molecular Weight: 200.692
• Mol File: 19380-80-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-chlorobenzyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorobenzyl)thiourea(19380-80-4)
• EPA Substance Registry System: 1-(2-chlorobenzyl)thiourea(19380-80-4)

Safety Data

• Hazardous Substances Data: 19380-80-4(Hazardous Substances Data)

Upstream product

• 333-20-0 potassium thioacyanate 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 306281-16-3 1-benzoyl-3-(2-chlorobenzyl)thiourea 
• 18967-44-7 o-chlorobenzyl isothiocyanate 

Downstream Products

• 91721-28-7 2-(2-chloro-benzylamino)-5-ethyl-thiazol-4-one 
• 93568-81-1 5-butyl-2-(2-chloro-benzylamino)-thiazol-4-one 
• 141771-20-2 1-(2-chlorophenyl)methyl-2-propyl-2-thiopseudourea 
• 91066-28-3 2-(2-chloro-benzylamino)-5-methyl-thiazol-4-one 
• 92854-15-4 2-(2-chloro-benzylamino)-5-(2-chloro-phenyl)-thiazol-4-one 
• 92854-16-5 2-(2-chloro-benzylamino)-5-(4-chloro-phenyl)-thiazol-4-one 
• 92873-47-7 2-(2-chloro-benzylamino)-5-phenyl-thiazol-4-one 
• 102589-13-9 2-(2-chloro-benzylamino)-thiazol-4-one 
• 108718-35-0 5,5-diethyl-1-(2-chloro-benzyl)-2-thio-barbituric acid 

Relevant articles and documents

Synthesis, biological evaluation, and metabolic stability of chlorogenic acid derivatives possessing thiazole as potent inhibitors of α-MSH-stimulated melanogenesis

A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against α-MSH. The inhibitory activity was improved by replacing an α,β-unsaturated carbonyl of previously reported caffeamides with thiazole motif. Surprisingly, compound 7d, one of the derivatives of dioxolane analogs, displayed the most potent inhibitory activity with an IC50 of 0.90 μM. Further studies on metabolic stability and bioactivation potential were also accomplished.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.