193821-09-9

Basic information

• Product Name: Benzoic acid, 4-[[(phenylmethyl)imino]methyl]-, methyl ester
• CAS NO: 193821-09-9
• Molecular Formula: C16H15NO2
• Molecular Weight: 253.301
• Mol File: 193821-09-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(phenylmethyl)imino]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(phenylmethyl)imino]methyl]-, methyl ester(193821-09-9)
• EPA Substance Registry System: Benzoic acid, 4-[[(phenylmethyl)imino]methyl]-, methyl ester(193821-09-9)

Safety Data

• Hazardous Substances Data: 193821-09-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 1679-64-7 Monomethyl terephthalate 
• 349491-81-2 N-benzyl-terephthalamic acid methyl ester 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 1355027-11-0 methyl 4-(1-(benzylamino)but-3-en-1-yl)benzoate 
• 190662-37-4 NSC 122451 
• 1059145-19-5 4-((benzyl(3-(1,3-dioxoisoindolin-2-yl)propyl)amino)methyl)-N'-phenylbenzohydrazide 
• 1059145-27-5 4-((benzyl(3-(diisobutylamino)propyl)amino)methyl)-N'-isobutyl-N'-phenylbenzohydrazide 
• 1059147-17-9 C₃₃H₃₅N₃O₃ 
• 1059145-23-1 4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide 
• 1059145-20-8 4-(((3-aminopropyl)(benzyl)amino)methyl)-N'-phenylbenzohydrazide 
• 1059145-17-3 N-benzyl-4-((benzylamino)methyl)-N'-phenylbenzohydrazide 
• 1059144-23-8 4-((benzylamino)methyl)-N'-phenylbenzohydrazide 
• 1059147-16-8 4-(((tert-butoxycarbonyl)benzylamino)methyl)benzoic acid 
• 1620323-31-0 (R)-1-benzyl-3,3-difluoro-4-(4-methoxycarbonylphenyl)azetidin-2-one 
• 1437798-32-7 methyl 3-benzyl-4-oxo-2-phenyl-3,4-dihydroquinazoline-7-carboxylate 

Relevant articles and documents

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral α-aminonitriles and α-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active α-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Iridium-catalyzed reduction of secondary amides to secondary amines and imines by diethylsilane

Catalytic reduction of secondary amides to imines and secondary amines has been achieved using readily available iridium catalysts such as [Ir(COE) 2Cl]2 with diethylsilane as reductant. The stepwise reduction to secondary amine proceeds through an imine intermediate that can be isolated when only 2 equiv of silane is used. This system requires low catalyst loading and shows high efficiency (up to 1000 turnovers at room temperature with 99% conversion have been attained) and an appreciable level of functional group tolerance.

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