19395-42-7

Basic information

• Product Name: 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE
• Synonyms: 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE
• CAS NO: 19395-42-7
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.29
• Mol File: 19395-42-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 349.6 °C at 760 mmHg
• Flash Point: 121.8 °C
• Appearance: /
• Density: 1.08 g/cm³
• CAS DataBase Reference: 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE(19395-42-7)
• EPA Substance Registry System: 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE(19395-42-7)

Safety Data

• Hazardous Substances Data: 19395-42-7(Hazardous Substances Data)

Usage

General Description

2-Phenyl-2-pyridin-2-yl-butyronitrile is a chemical compound with the molecular formula C17H14N2. It is a butyronitrile derivative with a phenyl and pyridin-2-yl groups attached to the carbon chain. 2-PHENYL-2-PYRIDIN-2-YL-BUTYRONITRILE is commonly used as a building block in the synthesis of various pharmaceuticals and other organic compounds. It is used as an intermediate in the production of drugs and agrochemicals, and it also has potential applications in research and development. The chemical's structure and properties make it valuable for use in the chemical, pharmaceutical, and agricultural industries.

Upstream product

• 140-29-4 phenylacetonitrile 
• 109-09-1 2-chloropyridine 
• 372-48-5 2-fluoropyridine 
• 769-68-6 2-phenylbutanenitrile 
• 626-05-1 2,6-Dibromopyridine 
• 74-96-4 ethyl bromide 
• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 

Relevant articles and documents

Mild and practical method for the α-arylation of nitriles with heteroaryl halides

A mild and transition-metal-free method for theα-arylation of a liphatic nitriles with activated heteroaryl halides was developed using NaHMDS o r KHMDS as base at ambient temperature. The key to the success of this method is generation of the nitrile anion in the presence of the heteroaryl halide. The method is applicable to both primary and secondary carbonitriles and a wide range of heteroaryl halides. Selective monoarylation was observed with primary carbonitriles. The operational simplicity and the mild reaction conditions add to the value of this methodas a practical alternative to the preparation of α-heteroaryl carbonitriles.

SRN1 Mechanism in Heteroaromatic Nucleophilic Substitution. Reactions Involving Certain Dihalogenated ?-Deficient Nitrogen Heterocycles

Photostimulated reactions of 2,6-,2,3-, 3,5-, and 2,5-dihalopyridines (1a-e) with pinacolone potassium enolate (2) in liquid NH3 lead to facile replacement of both halogens via a modified SRN1 mechanism, which does not involve intermediate formation of monosubstitution products.The potassium salts of phenylacetonitrile (12a) and α-ethylphenylacetonitrile (12b) react with 2,6-dibromopyridine (1a) under similar conditions to afford a mixture of mono- and disubstituted products via a related SRN1 process. 4,7-Dichloroquinoline (16) undergoes radical-chain displacement of chloride from C4 with enolate 2. 2,6-Dichloropyrazine (18) and 2,3-dichloropyrazine (20) also undergo monosubstitution with 2 and diisopropyl ketone potassium enolate (22), but these reactions appear to be mainly addition-elimination (SNAr) processes.Treatment of 3,6-dichloropyridazine (27) with 22 results in addition of 22 to C4 of the substrate.Photoassisted reaction of 2,4-dichloropyrimidine (31) with 12a leads to exclusive chloride displacement from C4 via the SRN1 mechanism.