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193962-59-3

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193962-59-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 193962-59-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,9,6 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 193962-59:
(8*1)+(7*9)+(6*3)+(5*9)+(4*6)+(3*2)+(2*5)+(1*9)=183
183 % 10 = 3
So 193962-59-3 is a valid CAS Registry Number.

193962-59-3Downstream Products

193962-59-3Relevant articles and documents

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site

Sall, Daniel J.,Briggs, Stephen L.,Chirgadze, Nickolay Y.,Clawson, David K.,Gifford-Moore, Donetta S.,Klimkowski, Valentine J.,McCowan, Jefferson R.,Smith, Gerald F.,Wikel, James H.

, p. 2527 - 2532 (2007/10/03)

In an effort to increase the thrombin inhibitory activity of a novel series of inhibitors (i.e., 1a), substituents were incorporated at the C-3' position of the C-3 aryl ring (2). Consistent with the X-ray crystallography studies, small hydrophobic groups at the C-3' site (Br and Me) enhanced thrombin inhibitory activity by 8-fold. However, a few more hydrophilic substituents (NO2 and OMe) also enhanced the potency of the series. The biological results are discussed in terms of molecular modeling studies.

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