193965-24-1

Basic information

• Product Name: 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-difluorophenyl ketone
• CAS NO: 193965-24-1
• Molecular Weight: 423.483
• Mol File: 193965-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-difluorophenyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-difluorophenyl ketone(193965-24-1)
• EPA Substance Registry System: 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-difluorophenyl ketone(193965-24-1)

Safety Data

• Hazardous Substances Data: 193965-24-1(Hazardous Substances Data)

Upstream product

• 76903-88-3 3,4-difluorobenzoyl chloride 
• 193965-55-8 6-benzyloxy-2-(dimethyl-amino)benzo[b]thiophene 
• 193965-54-7 α-(4-benzyloxyphenyl)-α-hydroxy-N,N-dimethylthioacetamide 
• 4397-53-9 p-benzyloxybenzaldehyde 

Relevant articles and documents

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[b]thiophenes

A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side chain by a cyclohexyl ring contributed to not only an additive but also a synergistic effect on the thrombin inhibitory activity. The SAR studies resulted in the discovery of a potent thrombin inhibitor 27 that was over 750-fold more potent than the initial lead compound 1.