194032-33-2 Usage
General Description
4-Fluoroisoquinoline-5-sulfonyl chloride is a chemical compound with the molecular formula C9H6ClFNO2S. It is a sulfonyl chloride derivative of 4-fluoroisoquinoline, containing a sulfonamide functional group. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a versatile building block in organic synthesis, particularly in the preparation of sulfonamide-containing compounds. 4-Fluoroisoquinoline-5-sulfonyl chloride has potential applications in medicinal chemistry and drug development due to its ability to react with various nucleophiles to form diverse chemical structures. However, it is important to handle this chemical with care, as it can be corrosive and may cause irritation to the skin and respiratory system.
Check Digit Verification of cas no
The CAS Registry Mumber 194032-33-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,0,3 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 194032-33:
(8*1)+(7*9)+(6*4)+(5*0)+(4*3)+(3*2)+(2*3)+(1*3)=122
122 % 10 = 2
So 194032-33-2 is a valid CAS Registry Number.
194032-33-2Relevant articles and documents
ROCK KINASE INHIBITORS
-
, (2020/05/29)
The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
A Practical synthesis of novel Rho-kinase inhibitor, (S)-4-fluoro-5-(2- methyl-1,4-diazepan-1-ylsulfonyl)-isoquinoline
Gomi, Noriaki,Ohgiya, Tadaaki,Shibuya, Kimiyuki,Katsuyama, Jyunji,Masumoto, Masayuki,Sakai, Hitoshi
experimental part, p. 1771 - 1781 (2011/09/21)
A practical synthesis of novel Rho-kinase inhibitor, (S)-4-fluoro-5- (2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride dihydrate (1) was achieved in a pilot-scale production. We have demonstrated the regioselective chlorosulfonylation of 4-fluoroisoquinoline in an one-pot reaction to afford 4-fluoroisoquinoline-5-sulfonyl chloride and the asymmetric construction of the (S)-2-methyl-1,4-diazepane moiety as key steps. The Japan Institute of Heterocyclic Chemistry.
