19406-86-1

Basic information

• Product Name: 3-Amino-4-methylbenzamide
• Synonyms: MAB;ATAD;3-AMINO-4-METHYLBENZAMIDE;3-amino-4-methyl-benzamid;3-amino-p-toluamide;Benzamide, 3-amino-4-methyl- (9CI);3-AMINO-4-METHYLBENZENE;3-Amino-4-methylbenzamide,98%
• CAS NO: 19406-86-1
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• EINECS: 243-039-0
• Product Categories: Intermediates of Dyes and Pigments;AMIDE;AMINEPRIMARY;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 19406-86-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 127-131 °C(lit.)
• Boiling Point: 271.72°C (rough estimate)
• Flash Point: 137.643 °C
• Appearance: Light brown/Crystalline Chunks
• Density: 1.1392 (rough estimate)
• Vapor Pressure: 0.0009mmHg at 25°C
• Refractive Index: 1.6180 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 16.47±0.50(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-Amino-4-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methylbenzamide(19406-86-1)
• EPA Substance Registry System: 3-Amino-4-methylbenzamide(19406-86-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 19406-86-1(Hazardous Substances Data)

Usage

Description

3-Amino-4-methylbenzamide is an organic compound characterized by its light brown crystalline chunks. It is a derivative of benzamide with an additional amino group at the 3rd position and a methyl group at the 4th position on the benzene ring. 3-Amino-4-methylbenzamide is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
3-Amino-4-methylbenzamide is used as a key intermediate for the synthesis of heteroaryl compounds, which are essential in the development of ERK1/ERK2 inhibitors. These inhibitors play a crucial role in the treatment of various diseases, including cancer, by targeting the extracellular signal-regulated kinases (ERK1/ERK2) involved in cell signaling pathways.
The compound's unique structure allows it to be a valuable building block in the creation of novel pharmaceuticals, making it an important asset in the field of medicinal chemistry. Its ability to form heteroaryl compounds with potential therapeutic applications highlights its significance in drug discovery and development.

InChI:InChI=1/C8H10N2O/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,9H2,1H3,(H2,10,11)

Upstream product

• 2458-12-0 3-amino-p-toluic acid 

Downstream Products

• 348165-94-6 3-(4,6-dichloro-1,3,5-triazin-2-ylamino)-4-methylbenzamide 
• 60710-80-7 5-cyano-2-methylaniline 
• 1622000-50-3 3-(4-(2-acrylamidophenylamino)-5-chloropyrimidin-2-ylamino)-4-methylbenzamide 
• 1621999-56-1 3-(4-(2-acrylamidophenylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-4-methylbenzamide 
• 960231-56-5 2-(5-Carbamoyl-2-methylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid 
• 1148050-97-8 3-(1-(2,5-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)-4-methylbenzamide 
• 1148050-94-5 3-(1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)-4-methylbenzamide 
• 1005196-66-6 C₁₇H₁₇N₅O₃ 
• 677781-30-5 (3-amino-4-methylbenzyl)carbamic acid tert-butyl ester 
• 1026000-70-3 (R)-3-{4-(5-Carbamoyl-2-methyl-phenylamino)-6-[((1S,2R,5S)-6,6-dimethyl-bicyclo[3.1.1]hept-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.