19408-46-9 Usage
Description
Kasugamyacin Hydrochloride Hydrate, derived from Streptomyces kasugaensis, is an aminoglycosidic antibiotic with potent antifungal properties. It functions by inhibiting protein synthesis in bacteria and interfering with the binding of aminoacyl-tRNA to the mRNA-30S ribosomal subunit complex, thereby blocking the initiation of translation.
Uses
Used in Pharmaceutical Industry:
Kasugamyacin Hydrochloride Hydrate is used as an antibiotic for treating bacterial infections. Its application is based on its ability to inhibit the initiation of translation in bacteria, effectively stopping protein synthesis and controlling the growth of the infection.
Used in Agriculture:
Kasugamyacin Hydrochloride Hydrate is used as a fungicide to control leaf and neck blast disease in rice crops, caused by Pyricularia oryzae. Its application in agriculture is due to its ability to inhibit the growth of the fungus, thereby increasing rice yields and protecting the crop from disease.
Used in Antifungal Applications:
Kasugamyacin Hydrochloride Hydrate is used as an antifungal agent to control various fungal infections. Its application in this field is based on its ability to inhibit fungal growth by interfering with the translation process in fungi, thus preventing the synthesis of essential proteins required for their survival and reproduction.
in vitro
kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].
in vivo
five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].
Metabolic pathway
kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There
is limited published information on its metabolism and environmental
fate but it is extensively degraded in plants and soil as indicated in
Scheme 1.
Degradation
kasugamycin hydrochloride hydrate is very stable at room temperature.
It is stable in weak acids but unstable in strong acids and under basic
conditions. Its DT50 values at 50 °C are 47 and 14 days at pH 5 and 9,
respectively (PM).
references
[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.
Check Digit Verification of cas no
The CAS Registry Mumber 19408-46-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,0 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 19408-46:
(7*1)+(6*9)+(5*4)+(4*0)+(3*8)+(2*4)+(1*6)=119
119 % 10 = 9
So 19408-46-9 is a valid CAS Registry Number.
